Study On Differentiation Potential Of Bone Marrow Multipotent Adult Progenitor Cells Into Epidermal Cells

We have successfully isolated homogeneous multi-linage multipotent adult progenitor cells (MAPCs) from adult rats'bone marrow through clonal culture. We had the first systemically compared the biological characteristics and differentiation potential of two stem cells derived from bone marrow:mesenchymal stem cells (MSCs) and MAPCs. It was demonstrated that MAPCs might be more primitive than MSCs. We had the first established the in vitro model of MAPCs differentiation into epidermal cells, in which MAPCs were transformed into epithelium-like cells. We also observed the influence of local skin injury environment on the migration and differentiation of MAPCs; the results confirmed that MAPCs could migrate to the injury site of skin and around the hair follicles and participated into skin healing by transforming into epidermal cells. Our findings not only contribute to the theoretical research of MAPCs plasticity, but also provided a theoretical evidence for clinical application of transplantation therapy.