| Hepatic ischemia followed by reperfusion is a major clinical problem occurring during transplantation, liver resection , shock, and so on. And the failure of liver often induced endotoxin translocation and endotoxemia, which aggravate live injuy. Therefore, hepatic ischemia-reperfusion and endotoxemia are considered to be the two key factors associated with perioperative liver injury.Recent studies suggest that volatile anesthetics isoflurane pretreatment is able to inhibit inflammatory reaction and reduce ischemia-reperfusion(I/R) injury. In our study, we investigate the effect of isoflurane pretreatment on inflammation reaction and hepatic Ischemia-Reperfusion injury combined with or without lipopolysaccharide in rats,and investigate the emulsified isoflurane pretreatment on the inflammation reaction and lung injury induced by hepatic I/R in rats. A model of segmental hepatic ischemia-Reperfusion injury combined with or without lipopolysaccharide in rats were used in our study. The HO-1 inducer and inhibitor were used to investigate the role of HO-1 in the mechanism of protective effect of isoflurane.The follows are the main conclusions: Isoflurane pretreatment might reduce the inflammation reaction and live injury induced by hepatic ischemia-reperfusion combined with or without lipopolysaccharide in rats ; Isoflurane pretreatment might increase the HO-1 expression in live tissue hepatic ischemia-reperfusion , and which reduce inflammation reaction and liver injury;Ischemia-reperfusion in liver induced evident inflammation reaction and lung injury in rats, which were significantly attenuated by emulsified isoflurane pretreatment.
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