Studies On The Total Syntheses Of Tardioxo-piperazine A, Isoechinulin A, Variecolorin A, C And Ambiguine L Isonitrile

This thesis main focused on the total syntheses of isoechinulin-type alkaloids: Tardioxopiperazine A, Isoechinulin A, and Variecolorin C. Meanwhile, syntheses of Variecolorin A and Ambiguine L Isonitrile are also studied. It consists of the following three chapters:Chapter 1:The recent development of cascade reactions and the applications in natural products syntheses (review)Some general examples illustrate the power of cascade reactions in diversity-oriented total synthesis, with particular emphasis on recent applications therein, meanwhile, several applications in natural products syntheses also were reviewed and the works of our group were introduced briefly.Chapter 2:Total syntheses of Tardioxopiperazine A, Isoechinulin A, Variecolorin C and studies on synthesis of Variecolorin ADiversity-oriented total syntheses of the isoechinulin-type alkaloids: Tardioxopiperazine A, Isoechinulin A, and Variecolorin C have been achieved from the common key intermediate, which derived from a regiocontrolled Stille cross-coupling reaction of allylindium. At the same time, we had tried some ways to complete the Variecolorin A.Chapter 3:Studies on synthesis of Ambiguine L IsonitrileDiversity-oriented total syntheses of the Ambiguine Isonitriles were described. By combining our previous work, the precise route study on the total synthesis of Ambiguine L Isonitrile has been further investigated.