Taipei Area Of ​​chronic Insomnia And Memory Impairment Related Survey And Intervention Study

Research one:Research of Correlation Survey between chronic insomnia and memory impairment in Taipei areaObjective:The research based on method of reviewing the literature, application of epidemiology investigation, evaluation of assessment scale. The study aimed to investigating general epidemiological situation of insomnia, the TCM symptoms, the TCM syndromes, differences of scores of each factor of SRSS in different TCM syndromes and memory function status in insomnia patients in Taipei area. The research also analyzed the correlation between chronic insomnia and memory function, provided epidemiological basis for TCM therapy to insomniacs in Taipei area, strived to develop a effective clinical questionnaire for insomnia patients.Method:1.This study chose 300 insomnia patients according to insomnia epidemiological diagnostic criteria, inclusion criteria and exclusion criteria in Taipei area. We observed the distribution of age, sex, education degree, profession of the patients.2.The doctors specialized in treating insomnia measured and filled in "TCM insomnia clinical questionnaire", learned the TCM symptoms, syndrome features of insomnia patients.3. Patients filled in the Self-Rating Scale of Sleep (SRSS), in order to learn the condition of insomnia as well as differences of scores of each factor of SRSS in different TCM syndrome.4. Evaluate the memory level of insomnia patients by clinical memory scale(CMS), inorder to find out the situation of memory deficits of chronic insomnia patients, and do the correlation analysis.Results:1. The patients are mostly elderly people. by education degree in primarily, Education degree mainly distributed in the college degree or above. The morbidity in mental labor people and unemployment people is higher. The condition of memory loss was similar with the detection rate in patients gender, age, educational level and occupational distribution.2. The top 15 symptoms of insomnia patients in Taipei area:taut pulse 76.00%, not easy to sleep 74.00%, insomnia and dreaminess 71.33%, forgetfulness 63.67%, irritability and susceptibility to rage 55.33%, dizziness 54.00%, belching 51.00%, dispiritedness 48.33%, frequent sigh 45.00%, shortness of breath and not desire to speak 44.33%, hypochondria pain and gastric discomfort 43.00%, purplish macules on the surface of the tongue 40.83%, easy to wake up, wake up early, wake up sleepy 37.66%, chest oppression and much sputum 36.67%, acid regurgitation 35.67%.3. The syndromes of insomnia patients in Taipei area:syndrome of liver qi stagnation and spleen asthenia (34.00%), asthenia syndrome of heart and spleen (28.33%), Blood stasis syndrome(14.00%), disturbance of the heart by phlegmatic fire(12.00%), syndrome of disharmony of the heart and kidney (11.67%).4. SSRS scale:More common in patients with liver spleen deficiency decreased sleep quality, difficulty falling asleep, sleep and sleep easily after waking dreams while other conditions; deficiency of both heart and spleen were not more common lack of sleep or wake, sleep time is shorter; phlegm disturbance of evidence More common in patients with difficulty falling asleep, dreams while sleeping, etc., of which more than a dream/nightmare even worse than the liver in patients with spleen deficiency; blood stasis syndrome more common sleep easily after waking situation.5. Patients with chronic insomnia in Taipei CMS Clinical Memory Scale test scores lower sub-frequency to low-and high image free recall, respectively (90.33%), associative learning (89.67%), point to memory (84.00%), nonsense figure Recognition (78.67%), Portrait Features Contact recall (72.33%), memory quotient score of<70 212 people,70.67% of the total survey population. CMS patients with insomnia and memory quotient of the sub-scores and the SRSS total score of each factor and the negative correlation between score and gender, age, educational level, SRSS total score and memory scores between the regression relationship between business.Conclusion:1.300 patients in the Taipei area with chronic insomnia were almost female, middle-aged, highly educated, mental, or unemployed people. The rate in patients with memory deficits were similar with gender, age distribution, educational level, occupation characteristics.2. Patients with chronic insomnia Taipei area behind former 15 symptoms were mainly the symptoms of liver qi stagnation and spleen asthenia. And TCM syndrome type of liver depression and spleen deficiency, heart and spleen deficiency, blood stasis permits the most common.3. In SSRS scale survey, different forms of insomnia had different types of TCM symptoms5. There was about 70.67% of patients with chronic insomnia in Taipei associated with memory deficits. Research two:Clinical Research of Shuganjianpi Therapy for Chronic Insomnia Patients with Memory Deficits Objective: Objective:Observing the influence in sleep quality, clinical symptoms, signs and memory levels of chronic insomnia patients with memory deficits inTaipei treated by Shuganjianpi therapy of Chinese herb, and evaluation the curative effect of Shuganjianpi therapy for insomnia.Method:Our research used randomized, parallel controlled clinical trial methods. We chose 60 patient met the diagnostic requirements of the memory deficits in patients with insomnia (TCM as the ganyupixu syndrome),and randomly divided into treatment group and control group. Treatment group used Shuganjianpi therapy of Chinese herbs, control group took estazolam tablets for 4 weeks. Observed Pittsburgh Sleep Quality Index (PSQI) scores, TCM syndrome, changes in symptom scores, memory function recovered,2 weeks,4 weeks as well as follow-up after 1 week TCM syndrome score and PSQI total score changes,inoder to evaluate the curative effect of ShuganJianpi therapy.Results:1.Treatment for 2 weeks, the treatment group PSQI sub-item and total score were improved than before treatment,group compared p<0.05, significantly different; control group PSQI score, in addition to the sub-items "sleep quality ","Sleep efficiency, "" daytime function, "compared with their pre-treatment p> 0.05, the difference was not statistically significant, the remaining sub-items and total score than those before treatment to improve, p<0.05, significantly different. After 4 weeks, the treatment group PSQI score and total score of the sub-items than before treatment improved group compared p<0.05, p<0.01, statistically significant differences, which in the "sleep efficiency", "Day between the function "and total scores were significantly higher than before treatment difference p<0.01; control group PSQI score and total score than the sub-item" sleep efficiency "," Day feature "(p> 0.05), but were improved compared with before treatment (p<0.05); between the two groups, in addition to "sleep time", "sleep disorders" (P> 0.05) difference was not statistically significant outside, PSQI score and the total breakdown of the remaining comparison groups (P<0.05), the difference was significant, the treatment group in the "sleep efficiency", "Day function" was superior to the control group improved (P<0.05), differences were significant.1 week follow-up, treatment group and treated for 4 weeks compared PSQI scores, p> 0.05, the difference was not statistically significant; the control group and treated for 4 weeks compared PSQI scores, p<0.05, significantly different; group Comparison, P<0.05, statistically significant difference.2. Clinical evaluation of individual clinical symptoms:two groups were observed after treatment of "sleep time "and"difficulty falling asleep, " the improvement in symptoms (P> 0.05), no significant difference; treatment were observed on the "easy wake""more than a dream""Sleepy fatigue "improvement of symptoms (P<0.05), with significant differences.3.Comparison of TCM symptom points:two points before treatment compared TCM symptom P> 0.05, the difference was not statistically significant, comparable; group 4 weeks after treatment compared to the treatment group compared with before treatment p<0.01, Significant difference, statistically significant, the control group before treatment p<0.05, significantly different; between the two groups, P<0.05, that TCM symptoms after treatment, both groups were statistically significant differences between points.1 week follow-up, the treatment group compared with 4 weeks of treatment, p> 0.05, the difference was not statistically significant; the control group compared with 4 weeks of treatment, p<0.05, statistically significant differences between the two groups were followed up 1 week PSQI total score Comparison, P<0.05, difference statistically significant.4. Chinese total effective rate was 89.66% symptom, compared with control group P<0.05, overall symptom efficacy of the two groups was significant difference.5. Memory Evaluation:After 4 weeks of treatmen' group in two groups in the five factor scores improved compared with before treatment, the difference was statistically significant (p<0.05, p<0.01); group compared with the control group Five factor scores were significantly better than the improvement of the control group, the difference was statistically significant(P<0.05).Conclusion:1. ShuganJianpi therapy of Chinese herb can improve sleep quality more sustainly and stably, and has good long-term effect.2. ShuganJianpi therapy of Chinese herb can improve the patients individual symptoms, TCM symptom score and total effective rate of TCM symptoms effectively.3.ShuganJianpi therapy of Chinese herb can effectively improve memory dysfunction in patients with chronic insomnia, improve memory levels, enhance the quality of life...