Modern Literature Research On Premature Ovarian Failure (POF)

ObjectiveThe study intends to systematically analyze the etiopathogenisis, etiology, the differentiation, treatment and medication laws about premature ovarian failure (POF) that were discussed in modern literature. MethodsAdopting the bibliography and statistics methods together, the author establishes the pathogenesis, the differentiation, treatment and medication databases. With pykno-statistical methods, the author systematically analyzes modern physicians'understanding about POF and their medication features. The author studies and sorts out the high-frequency medications on POF and finds out the basic prescriptions and medicine for POF treatment.ResultsRenal deficiency and essence deficiency occupies the largest proportion of all pathogenesis and etiology, i.e.23.23%.927 kinds of Chinese Herbal Medicine are used, among which 532 are tonics, occupying 57.39% and ranking the first place; 147 are drugs for invigorating blood circulation and eliminating stasis, occupying 15.86% and ranking the second; 57 are heat-clearing and fire-purging drugs, occupying 6.15% and ranking the third. According to the prescription analysis principles in statistics, if the drugs with accumulated frequency above 50% are combined to be one dosis, then the prescription should be angelica, prepared rhizome of rehmannia, cuscuta seed, fructus lycii, herba epimedii and radix paeoniae alba.Conclusion1. Pathogenesis and etiology of POF:dysfunction of kidney, liver, spleen and heart is the fundamental etiology, among which renal deficiency is the foundation; the dysfunction of liver, spleen and heart and the deficiency of kidney are mutual causes and results; qi deficiency and blood stasis is the important pathogenetic cause. Renal deficiency and essence deficiency are the most basic etiology.2. Basic thoughts and methods for POF treatment:①Adjust zang and fu organs' function. Take invigorating the kidney as the major method and replenishing spleen and heart, adjusting liver and clearing pathogenic fire as the complementary method.②Cure the root of disease and take care of the appearance and substance a the same time. Invigorating blood and dissolving stasis is the common method.③Treat POF with Chinese Herbal Medicine by different stages and establish the natural cycles.④Combining Chinese Medicine and Western Medicine together to treat POF is the effective way.⑤Treat physically and psychologically to improve the efficacy.⑥Active prevention may reduce the incidence of diseases.3. The basic medication combination adopted by modern physicians to treat POF are angelica, prepared rhizome of rehmannia, cuscuta seed, barbary wolfberry fruit, herba epimedii and radix paeoniae alba.