The Viral Etiology Research Of Trigeminal Neuralgia Combined Arachnoids' Adhesions

Objective:To assess the relationship that trigeminal neuralgia combining arachnoids'adhesions and herpes simplex virus type 1.Methods:There are fifty nine patients with trigeminal neuralgia their trigeminal nerve root area combined arachnoids' adhesion, cutting their arachnoids as the experimental group. There are twenty four patients with trigeminal neuralgia their trigeminal nerve root area is not combined significant arachnoids' adhesion, cutting their arachnoids as the case-control group. Using polymerase chain reaction and Western blot technique to detecting the HSV-1 specific DNA fragments and specific antigen, and cutting twenty arachnoids of the patients with Brain Trauma as the normal control group.Results:The positive ratio of DNA fragments in the three group is 69.49%,58.33% and 25% respectively. The positive ratio of DNA fragments in the experiment group and case-control group were higher than the normal control group, with statistical difference(p<0.05), but the experimental group and case-control group compared with no significant difference(p>0.05). The positive ratio of virus-specific antigen is 50.85%,25% and 15% respectively. The positive ratio of virus-specific antigen was higher than the case-control group, also higher than the normal control group, were significantly different(p<0.05), while the case-control group and the normal control group compared with no significant differences(p>0.05).Conclusion:HSV-1 proliferating infected patients with trigeminal neuralgia may result in the arachnoids adhesion of trigeminal nerve root zone; arachnoids tissue may be another latent base of HSV-â… ; HSV-â… infection may be another pathogenic factor of trigeminal neuralgia.