The Study On The Dialectical Therapy And Simple Neoclitide Polymorphism Of Thyroid-associated Ophthalmopathy

Objective:Choose the TAO(Thyroid-associated ophthalmopathy) patients as the objects and study on the TCM dialectical therapy and the SNP(Single Nucleotide Polymorphism) situation of this disease for the further study on the clinical effects of TCM dialectical therapy and the pathogenisis of this disease. Methods:Divide all the patiens into 3 groups based on thieir different clinical manifestation and TCM dialetical diagnosis theory and then use Chinese herb drugs to treat them and observe the clinical effects;Meantime detect these patients' blood samples to superficially discover the situation of TAO's patients some cytokines and inflammatory factors's SNP based on the pathogenisis of TAO and the hereditism rules. Results:By observing the analysis of the types of the detected cases, hyperthyroidism merging with prominent eyes focused on excessive hotness of liver type, Yin deficiency of 1 iver and kidney, and the type of deficiency of spleen's qi and excessive moist indicating clinical syndrome type has relative concentration. Two groups body symptoms and signs before and after the treatment of TCM syndrome by statistical analysis, evaluation and analysis of dialectical therapy to improve TAO systemic comprehensive symptoms were obviously improved; Better than western medicine control group.Syndrome differentiation and treatment group before and after the treatment prominent eyes obviously improved, a significant degree of difference (P< 0.05), western medicine control group before and after the treatment prominent eyes improvement, but the degree of visible statistical processing, no significant difference (P> 0.05)Syndrome differentiation and treatment group (before and after the treatment significantly improved exophthalmos significant difference (P< 0.05). Eye bloated, tears, photophobia, eyelid edema symptoms, both groups can significantly improve; Hyperthyroidism merger by TCM syndrome differentiation and treatment eye axon eye local symptoms improve significantly better than western medicine circumstance comparator treatment group. Thyroid correlation with Thyroid-associated Disease (TAO) suffered CTLA pixu 4 AG in genotype differences, the two groups may reflect the differences between different unionizing and viscera in liver-kidney Yin deficiency distinction, and with the above two groups, and no difference does liver-kidney Yin deficiency existing. The testing results of that there are certain rules existing on the genetic loci.Conclusion:1, syndrome differentiation and treatment group of TAO systemic comprehensive symptoms were obviously improved; Better than western medicine control group.2, syndrome differentiation and treatment group before and after the treatment prominent eyes obviously improved, a significant degree of difference (P< 0.05), better than western medicine in control group (P> 0.05)3,eye local clinical manifestation, diagnosis and treatment of traditional Chinese medicine to improve treatment group than western medicine control group.4, TAO syndrome types related by SNP detection proof that there are some certain rules existing among different TAO synfrome types on the polymorphism for the nucleotide of the genes from those patients.