| ObjectiveChronic renal failure (CRF), a chronic renal parenchymal damage caused by a variety of reasons, causes severe damage to the renal unit, the slow onset of renal dysfunction to irreversible renal failure that is the final consequence of a variety of development of kidney diseases. According to the statistics of the International Society of Nephrology, the natural populations of the disease incidence of approximately0.01to0.02%, and showing an upward trend after five year, it is a serious threatening to the human health. With the long period of disease, difficult to treat, high mortality, etc. are the reasons of great suffering and economic burden to the society and family. Western conservative treatment effect is not satisfactory. Dialysis therapy and kidney transplantation can prolong life but the high cost of treatment is often difficult to afford by many patients and their families. Therefore, actively looking for an effective method of treatment for this disease and further improve the clinical efficacy has very important significance. In recent years, use of traditional Chinese medicine as the method of treatment to delay CRF progress has drawn the world's attention. Scientists are working deeply in theoretical, clinical and experimental research and achieved gratifying results. So, the looking for positive development methods to use traditional Chinese medicine to treat CRF has a bright and very broad prospect. The pathological mechanism of the CRF aiming at failure of spleen and kidney, turbid stasis of professor Tang Shui Fu combines a modern medical science to study an achievement and makes use of Tongfu Xiezhou and Yiqi Huoxue treatment CRF, the curative effect is accurate. Pass this research usage Tongfu Xiezhou and Yiqi Huoxue to cure CRF, and evaluate its influence for sufferer kidney function, and lipid, hemodynamic factor and T lymphocyte subsets is second cluster of the variety wait to in many ways inquire into its function mechanism.MethodA randomized, controlled the principle of inclusion criteria to48patients according to CRF in patients with a3:1ratio were randomly divided into treatment group36cases and control group12cases. Two groups correspondingly control of high-quality low-protein diet, correcting water, correcting electrolyte, acid-base balance disorders, correcting anaemia, deal with blood pressure, blood glucose, blood fat, edema serious use diuretics, merge to be infected to give an antibiotic. Treatment group in addition to the above basic treatment, added to use Tongfu Xiezhou and Yiqi Huoxue, the basic constitutes:Rhizoma Pinelliae10g, Fructus Aurantii10g, Caul is Bambusae10g, Glabrous Greenbrier Rhizome30, Leguminosae30g, Savia miltiorrhiza15, peachseed10g, Rheum palmatum10g, Herba Centellae30, Sophora japonica15g, Citrus reticulata15g. Decoction of the medicine in water,2times oral, every day. Two groups were treated for2months and observed clinical effects and changes in clinical symptom score, measuring renal function (BUN, Scr),24-hour urine protein, routine urine, electrolyte, uric acid (UA), blood glucose, plasma protein, total plasma protein, blood fat, hemodynamic factor (NO,ET,NO/ET) and T lymphocyte subsets (CD3,CD4, CD8, CD4/CD8) of change.Result1. The symptom scores after treatment compared with before treatment significantly decreased (P<0.01) and showed that two groups can improve the clinical symptoms of CRF. The study group improved more significantly in clinical symptom score, compared with the control group, the difference was statistically significant (P<0.01). Treatment group was more significantly improved clinical symptom score, treatment group is declined11.7±6.3score; with control group is decerased9.8±7.2score.2. Two groups after treated, although the24h urinary protein steadily decreased, but in comparison with the before the difference was not statistically significant (P>0.05).3. Two groups after treated, Total protein, Albumin were significantly increased compared with before treatment and the difference was statistically significant (P<0.05). 4. The treatment group TC, TG of LDL-C levels was significantly decreased. HDL-C levels were significantly increased compared with before treatment and the difference was statistically significant (P<0.05). Control group, although TC, TG of LDL-C levels was steadily decreased and HDL-C value were slightly increased after treatment, but in comparison with the before the difference was not statistically significant (P>0.05).5. The treatment group red blood cell and hemoglobin average value were significantly increased with different levels compared with before treatment. The difference was significant (P<0.05). Control group, although above index were slightly increased after treatment, but in comparison with the before the difference was not statistically significant (P>0.05).6. The treatment group renal function indexes BUN, Scr were improved with different levels, Ccr value were significantly increased compared with before treatment, the difference was significant (P<0.05). Control group, although renal function indexes BUN, Scr steadily decreased and Ccr value were slightly increased after treatment, but in comparison with the before the difference was not statistiacally significant (P>0.05).7. The treatment group CD3,CD4,D4/CD8value were significantly increased, CD8value was significantly decreased compared with before treatment, the difference was significant (P<0.05). Control group, although CD3, CD4, CD4/CD8value steadily increased and CD8value were slightly decreased after treatment, but in comparison with the before the difference was not statistically significant (P>0.05).8. The treatment group NO, NO/ET value were significantly increased, ET value was significantly decreased compared with before treatment, the difference was significant (P<0.01). Control group, although NO, NO/ET value steadily increased and ET value were slightly decreased after treatment, but in comparison with the before the difference was not statistically significant (P>0.05).After02months of treatment, the study group,8of36cases are markedly effective,9of36cases are effective,15of36case were stable and4of36cases are not effective, total effective rate was88.9%. The control group that1of12cases is markedly effective,2of12cases are effective,3of12cases were stable and6of12cases are not effective, total effective rate was50%. The study group in comparison with control group the treatment effects with the difference was significant (P<0.05).ConclusionThe results showed that-1. Use of Tongfu Xiezhuo and Yiqi Huoxue to treat CRF patients, after treatment, improves clinical symptoms and decreases urinary protein, and improve kidney function and lipid metabolism, and improve anemia and nutritional status.2. Use of Tongfu Xiezhuo and Yiqi Huoxue to treat CRF patients, after treatment, improves T lymphocyte subsets:CD3, CD4, CD4/CD8value were significantly increased, CD8value was significantly decreased compared with before treatment.3. Use of Tongfu Xiezhuo and Yiqi Huoxue to treat CRF patients, after treatment, improves hemodynamic factor:NO, NO/ET value were significantly increased, ET value was significantly decreased compared with before treatment.4. Use of Tongfu Xiezhuo and Yiqi Huoxue therapy of CRF with good results, progress through the multi-link delay renal function decline, which improve lipid, improve the T lymphocyte subsets and hemodynamic factor are on of the main mechanism of the protective effects on renal function.
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