The Changes Of Hepatic Apparent Diffusion Coefficient And Perfusion Ct Parameters In Patients With Tumor During Chemotherapy

ObjectivesThe aim of this study is to investigate changes in the hepatic apparent diffusion coefficient (ADC) in patients undergoing chemotherapy.MethodsWe enrolled54patients (25women; mean age57.0±13.1years, range29-89years) undergoing chemotherapy for tumor and10controls (7women; mean age55.1±17.5years, range23-81years). The patients were tested for serum alanine aminotransferase (ALT) activity (abnormal, normal) and fatty liver. Hepatic ADC values were compared among controls, patients and subgroups. Pearson correlation coefficient was used to assess the correlation between ADC and ALT activity.ResultsHepatic ADC(0,850)(×10-3mm2/s) was lower for patients than controls (1.14±0.18vs.1.28±0.12, P=0.02) and was lower for patients with than without fatty liver and controls (1.01±0.06vs.1.18±0.18and1.28±0.12, respectively, all P<0.01), with no significant difference between patients without fatty liver and controls (P=0.07). ADC(0,850) was lower for patients with abnormal ALT than normal ALT activity and controls (0.99±0.06vs.1.17±0.18and1.28±0.12, respectively, all P<0.05), with a significant difference also being seen between patients with normal ALT activity and controls (P=0.04). Hepatic ADC(0,850) was not correlated with ALT activity in patients (r=-0.24, P=0.08).ConclusionsChemotherapy affects hepatic ADC value in patients with tumor and the changes in hepatic ADC value can be quantitatively assessed by DW-MRI. AimTo investigate the microcirculation changes in liver of patients with tumor during chemotherapy by perfusion computed tomography (PCT).MethodsSixty patients with tumor and20controls were enrolled in this study. Perfusion CT parameters of patients and controls were compared, including hepatic perfusion index (HPI), mean transit time (MTT), and permeability-surface area product (PS). Correlation between perfusion CT parameters, treatment cycle and alanine aminotransferase (ALT) level was studied.ResultsNo difference was found in HPI (25.68%±7.38%vs.26.82%±5.13%), MTT (19.67±5.68s vs.21.70±5.43s) and PS (17.00±4.56ml/100ml/min vs.19.92±6.35ml/100ml/min) between patients and controls. The HPI and MTT were significantly higher in patients undergoing2cycles of chemotherapy than in controls and those undergoing1cycle of chemotherapy (29.76%±5.87%vs.25.68%±7.38%and25.35%±4.05%, and25.61±5.01s vs.19.67±5.68s and19.74±4.54s, respectively, P<0.05). The HPI was higher in patients with hepatic steatosis than in controls and those without hepatic steatosis (30.85%±6.17%vs.25.68%±7.38%and25.70%±4.24%, P<0.05). Treatment cycle was well correlated with HPI and MTT (r=0.40, r=0.50, P<0.01). ALT level was not correlated with perfusion CT parameters.ConclusionsChemotherapy affects hepatic microcirculation in patients with tumor. Changes in hepatic microcirculation can be quantitatively assessed by perfusion CT.