The Clinical Application Of Diffusion-weighted Imaging In Liver Diseases

Objective:To investigate the clinical value of DWI in the diagnosis and differential diagnosis of liver benign and malignant space occupying lesions.Materials and Methods:GE1.5T superconductive MR scanner, conventional sequence+DWI, check the line of70cases of liver space occupying lesions, including30cases of liver cancer,20cases of liver metastases,20cases of hepatic hemangioma.Figure DWI and ADC map analysis of a variety of lesions characteristics and measurement of lesion apparent diffusion coefficient.Results:Liver cancer and liver metastases in the diagram on DWI most of the performance level of mixed signal lesions substantial part of the high signal, necrosis of the cystic part of the low signal, the clear boundary; ADC map was or slightly higher signal. Hepatic hemangiomas showed high signal on DWI map with clear edge; most of the ADC map was or high signal. The three lesion ADC values were:liver cancer (1.45±0.13×10-3mm2· s-1), liver metastases (1.37±0.18×10-3mm2· s-1), liver hemangioma (2.44±0.25×10-3mm2· s-1); hepatic hemangiomas and liver cancer, liver metastases compared, the difference was significant and statistically significant (P<0.05); differences in liver cancer and liver metastases, no significant difference (P>0.05). Primary hepatocellular carcinoma/liver ADC value ratio0.93±0.27, of liver metastases of the cancer/liver ADC value ratio1.10±0.32, the difference was statistically significant.Conclusions:The application of DWI, greatly improving the ability of MR in the diagnosis and differential diagnosis of hepatic malignancies. Objective: By comparing the diffusion-weighted imaging (DWI) and multi-phase enhanced MSCT scan of liver cancer detection sensitivity, specificity, positive predictive value and negative predictive value to assess the value of DWI for the Value of liver cancer.Materials and Methods:CT scan of the55cases of patients with suspected liver MRI scan+DWI and conventional multi-phase enhanced MSCT scan. By the two senior titles, double-blind diagnostic imaging physicians read the piece, the diagnosis of views to reach agreement, statistical methods for two kinds of small hepatocellular carcinoma check (diameter<3cm) and non-small HCC (diameter>3cm) lesion detection sensitivity, specificity, positive predictive value and negative predictive value; and two kinds of inspection methods for the diagnosis of small hepatocellular carcinoma subjects ability to line working curve (ROC) analysis.Results:For small liver lesions, DWI for lesion detection sensitivity, specificity, positive predictive value and negative predictive values were94.4%,50%,94.4%,50%, while the multi-phase enhanced MSCT scan was55.6%,50%,90.9%,11.1%; for non-small liver lesions, DWI for lesion detection sensitivity, specificity, positive predictive value and negative predictive values were89.4%,66.7%,97.2%,33.3%, while MSCT92.3%,33.3%,94.7%,25%.For small liver lesions, ROC area under the curve of average0.944higher than the DWI check the way for multi-phase enhanced CT scan method0.889, and the difference was statistically significant (P<0.05).Conclusions:DWI help to improve the application of small liver cancer, especially liver cancer detection sensitivity、positive predictive value and negative predictive value.