The Ziyin Yiqihuoxue Prescription Treatment Of Diabetic Nephropathy Of The Study

Diabetic nepbropathy is the main microangiopathic complications of diabetes and the major causes to death. It includes five stages: I phase(high rate stage of glomerulus filtration rate), II phase(quiescent stage), III phase(occult stage), IV phase(dominant stage), V phase(renal failure stage). The main contents of the study including: (1) R鐅eal Tradition Chinese Medicinal pathomechanism and disease cause of diabetic nephropathy according to dissert of wasting-thirst in all dynasty and development of treating diabetic nephropathy with chinese medicinal. (2)Discuss the method of making diabetic nephropathy model. (3)Observe the effects of decreasing blood sugar and kidney-enriching formula to renal stracture and function of diabetic nephropathy model of rat caused by STZ, hyperlipin feed and renal hemiresection. Reveal its mechanism on the aspect of pathology, carbohydrate metabolism, renal hemodynamics and blood lipin through the contradistinctive and classified research on the medicinal constituent of the formula. (4)Reveal the mechanism of the formula抯 effect on cell factor impacting diabetic nephropathy. (5)Treat 62 diabetic nephrosis patients: confirm the effectivity of decreasing blood sugar and kidney-enriching formula framed by method of enriching yin, boosting qi and blood quickening, and analyse the elementary mechanism.The results showed as follow:1 .Diabetic nephropathy is included in categories of 搘asting-thirsting?and 搇ower-wasting? whose mechanism of TCM always intricacy. The origin of its vacuity is kidney vacuity that included kidney original vacuity and kidney secondary vacuity caused by super dryness-heat of urpper and middle burner. The key reason of lower-wasting is kidney water more injuried, The important pathomechanism is fire and water failing to processSin kidney. The major reason caused exacerbation and weakness is that detriment to yin affects yang. After a long time will produce blood stasis because of blood vessel flow stoppage, blood stasis is the important factor causing patient抯 condition developmental worsening and going through all clinical courses. So the therapy should be vacuity-supplement and lustrating repletion. In chief enrich kidney yin in Vacuity-supplement, enrich qi to give support weakness of other viscera at the same time and consoci ate quickening the blood and transform stasis so that treat the root and tip simultaneously.2.Observe the effects of high lipin feed and renal hemiresection to 2 type diabetic rats caused by STZ, the results show that the GFR rise significantly in group of STZ adding operation and high lipin feed. The blood sugar of edit after 2h in groups of feeding with high lipin feed is higher than in groups only use STZ. The effects to kidney function of groups of STZ adding high lipn feed is lower than STZ groups of adding high lipin feed and operation. The results reveal that the model caused by STZ adding high lipin feed and operation is the most similar model to 2 type diabetic nepbropathy.3.Observe the formula抯 effects to the diabetic nephropathy rat model cause by small dose STZ injured, high 11pm feed and hemiresection, the results showed that can decrease significantly blood sugar after diet 2h, control availably hyperplasia of glomerulus mesenteric cell, inhibite tumefaction of glomerulus capillary endothelial cell, keep integrality of podocytic process and basement membrane, relieve vasal cavum stricture, reduce the GFR and excretory rate of ~ 2-MG, improve the status of high blood lipin, specially decrease significantly TC, reduce the TXB2 and T/K, improve the status of micro circulation obstacle, elevate the activity of NatK~-ATP enzyme. All prompt that the formula can improve the status of high hyper梡erfusion through joining glycoregulation, lipin metabolism and improving status of hamodynamics.4.The results of contradistinctive study between enrich yin, boosting qi drugs and promoting blood drugs in the formula show that enrich yin,boosting qi drugs can reduce the blood s...