| Objective: Gastrointestinal dismotility caused by many kinds of reasons is one group of disease as characteristic of delayed gastric emptying and hypoperistalsis of intestine, and it is common pathologic change of numerous functional digestive canal diseases. In addition, some organic digestive canal diseases, such as peptic ulcer, chronic gastritis and carcinoma of stomach , etc. , have gastrointestinal dismotility at the same time. In modern society, because the competition is aggravated , the rhythm of life is accelerated, people' s spirit is more and more tense , the excitability of the vagus nerve is strengthened ,which makes the emergence of disease of gastrointestinal dismotility rise. In recent years, according to the prevention and cure of gastrointestinal dismotility, the foreign scholars have launched the study on medicine of urging the power of intestines and stomach extensively. In the developed country, the costing for researching and developing new medicine of urging the power of intestines and stomach is up to 1 billion dollars equally every year. Some medicines, such as metoclopramide, domperidone, cisapride, etc., have already been applied at clinic. But curative effect and range of application of these medicines are still not ideal, and these medicines have lots of side effects to the central nervous system, circulatory system, and so on. Our country does not develop ideal medicines of urging the power of intestines and stomach either at present. It is discovered that XFDZT has remarkable curative effect to various kinds of disease of gastrointestinal dismotility. This subject makes the rat' s model of gastric dismotility with the liquorice decoction of certain dosage , in order to observe XFDZT ' influence on brain-gut peptides content and 5- HT APUD cell figure and brain-gut peptides receptor mRNA expressing in rat's blood or gastric antrum. This will offer the scientific theoretical foundation for widening XFDZT clinical practice and development of medicine.Methods: Firstly, made the rat's model of gastric dismotility with the liquorice decoction: 30 Wistar rats were divide into normal group, model group of 3 days and model group of 7 days at random, and every group had 10 rats (male and female rats were half and half). After giving liquorice decoction to rats, we tested rat' s stomach T1/2 with radioactive nuclide mark. Then 70 Wistar rats were divided into normal group(10 rats) and model group(60 rats) at random. Each rat of model group was irritated stomach with liquorice decoction(l0g/kg of weight). After irritated stomach at third day, 60 rats were divided into model group, model group of 3 days, model group of 7 days, low, hit, high dosage groups of XFDZT, group of domperidone .Except model group of 3 days, at the beginning of the fourth day, the rats of every other group were irritated stomach with liquorice decoction at 8:00a.m., and were cured 4:00p.m. Experiment wasfinished at seventh day. Then tested brain-gut peptides content in blood and gastric antrum with radioimmunopercipitation assay and 5- HT APUD cell figure with immunohistochemical method and brain-gut peptides receptor mRNA express with orthotopic hybridization.Results: (1) Liquorice decoction of certain dosage could lengthen rat's stomach T1/2, and there was significance difference between model groups and normal group (P<0. 05 or P<0. 01). In rat's blood and organization of model groups, MTL,GAS and SP content were reduced , compared with the normal group, there was significance difference (P<0. 05 or P<0. 01 ) ; VIP and SS content rised obviously, compared with the normal group, there was significance difference (P<0. 05 or P<0. 01). 5-HT APUD cell figure and area reduced obviously, and there was extraordinary significance difference between model groups and normal group (P<0. 01). Average ligh density of cell that had GASR mRNA express obviously reduced, and average grey level rised, and there were extraordinary significance difference between model groups and normal group (P<0.01); Average high density of cell that had...
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