Aconite Licorice Drug Combination Components Attenuated Mechanism

Objective: Researching the component parts toxicity of acontum fischeri mankshood and liquorice root ,and discussing the hylic base and mechanism of reductive toxicity after compatibility between them.Methods: To observe component parts toxicity of acontum fischeri mankshood fatsoluble alkaloid, acontum fischeri mankshood water-solubility alkaloid, acontum fischeri mankshood amylose, liquorice flavone, liquorice saponin by acute virulent animal experiment. To establish the rats arrhuthmic animal mldel with the biggest toxicity component part, acontum fischeri mankshood fatsoluble alkaloid,and observe the function to this arrhuthmic animal mldel with the component parts of acontum fischeri mankshood and liquorice root. In order to observe component parts alexipharmic effect and mechanism of acontum fischeri mankshood and liquorice root to acontum fischeri mankshood fatsoluble alkaloid toxicity on exosomatic germinal incubatory myocardial cell.With the methods of MTT, serum pharmacology, Giemsa staining ,electron microscope,cell enzymology.Results: The poisonous component parts are acontum fischeri mankshood water-solubility alkaloid and acontum fischeri mankshood fatsoluble alkaloid,The biggest poisonous component part is acontum fischeri mankshood fatsoluble alkaloid.The acontum fischeri mankshood amylose, liquorice flavone, liquorice saponin are no toxicity. The antiarrhythmic component parts are acontum fischeri mankshood water-solubility alkaloid and liquorice saponin . Acontum fischeri mankshood amylose and liquorice flavone have no antiarrhythmic function. The compatibility of acontum fischeri mankshood water-solubility alkaloid and acontum fischeri mankshood fatsoluble alkaloid can increase myocardial cell vitality,debase cultural myocardial cell apoptosis, vindicate the integrality of cytolemma, chondriosome , rough endoplasmic reticulum , ribosome , myofilament, raise enzymatic vigor,but acontum fischeri mankshood amylose, liquorice flavone, liquorice saponin can't.Conclusions: The poisonous component parts are acontum fischeri mankshood water-solubility alkaloid and acontum fischeri mankshood fatsoluble alkaloid,The biggest poisonous component part is acontum fischeri mankshood fatsoluble alkaloid,which result in animal arrhythmia.The antiarrhythmic component parts are acontum fischeri mankshood water-solubility alkaloid and liquorice saponin .Acontum fischeri mankshood amylose and liquorice flavone have no antiarrhythmic function. Acontum fischeri mankshood amylose can antagonize acontum fischeri mankshood fatsoluble alkaloid toxicity on myocardial cell.