| ObjectiveTo recognize the potential and the feasibility of nHAC/PLA material in the process of repairing overlength and/or huge bone defect, such as repairing a 40 mm long canine radial defect and performing canine anterior lumbar approach interbody fusion about 12mm × 12mm × 8mm.Material and methodsStudy of the biomechanics properties of nHAC/PLA: The material in a normal and a soaked condition were tested by the Biomechanical test machine. The biomechanics properties of nHAC/PLA were informed such as the strength of anti-compression, maximal compressive load, destroy stress, maximal elastic compressive strain, anti-torsional rigidity, torsional rigidity and so on.Establishment of a 40 mm canine radial defect experimental model and its approach: The canine forelimbs were anatomized. The fixation plate was designed and made according to the date from measured the canine radii for the defect model. A 40 mm canine radial defect model was performed by mimic the actual operation. Finally the strength of this fixation system was tested.Study of repairing a 40 mm canine radial defect using nHAC/PLA: A 40 mm canine radial defect was filling with nHAC/PLA, nHAC/PLA+BMP, and autograft. The defect was investigated by X-ray, bony nuclide scanning, 3-D CT reconstruction, and histological section at the 3 month, 6 month and 1 year post-operationally.Performing anterior lumbar approach interbody fusion: The defect was filling with nHAC/PLA, nHAC/PLA+BMP, and autograft, and then detected by X-ray and histological section at the 3 month, 6 month and 1 year post-operationally.ResultsThe strength of nHAC/PLA is weak at the peak about 0.65MPa similar with that of... |
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