Yiqihuoxue Spleen Law Lipid Lowering Efficacy Observed With The Apoe Gene Polymorphisms In Clinical Research

Objective:1.To observe the serum-lipid effect of TIAOZHI TONGMAI granule directed by method of YIQI HUOXUE HUATAN.2.Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to study the genotypes and allelic frequencies of QIXU TANYU syndrome population in hyperlipidemia, at the same time, analysis the effect of ApoE gene polymorphism on serum lipid.3.Furthermore to ascertain the effect of gene polymorphism on the method of YIHUOHUOXUE JIANPIHUATAN and the relationship between gene and drug effect.Method: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect apoE genotype in 118 hyperlipidemia patients, according to random, double blind, double imitate and control principle, the course of treatment is 8 weeks. Experimental group has 64 patients, giving TIAOZHI TONGMAI granule, 1 big, bid, po, XUEZHIKANG placebo 2 grain, bid, po. Control group has 54 patients, giving XUEZHIKANG capsule 2 grain, bid, po, TIAOZHI TONGMAI granule placebo 1 bag, bid po. To observe the change of TC,LDL-C,TG,HDL-C,apoA1,apoB,LP(a),AI , TCM syndrome and blood flow between pretreatment and posttreatment.Result:1.The total effective rate in regulating serum lipid of experimental group is 84.3%,decreacing TC,LDL-C,TG,apoB,AI, increasing HDL-C)(p﹤0.05), there are significant difference comparing to pretreatment. The total effective rate in regulating serum lipid of control group is 86.5 %, decreasing TC,TG,LDL-C,apoB,AI, increasing HDL-C)(p﹤0.05), there are no difference between experimental and control group. XUEAHIKANG group is better than TIAOZHITONGMAI granule group in lowing LDL-C. The effect on regulating serum lipid of TIAOZHITONGMAI granule is correspond to XUEZHIKANG, furthermore it can resist atherosclerosis. Tow groups can improve blood flow index, the station of increasing mocusity, thick and assemble in hyperlipidemia. TIAOZHITONGMAI granule is superior to XUEZHIKANG in improving TCM syndrome.2.Four genotypes are found in 118 patients,ε3 is the highest accounting for 65. 6%.The frequency of E2/3,E3/3,E2/4, E3/ are 8.5%,78%,1.7%and 11.9% respectively .There are not significant difference between men and women . Compared with Beijing natural population, the genotypes and allelic frequencies...