Long Baicalensis Grass, Tongluojiu'nao Brain Recipe Ingredients Pharmacy, Pharmacodynamics And Mechanism Of Action

Objective:Modern preparation of traditional Chinese drug should have some advantage, such as high performance, immediate effect, prolonged action, minidose, hypotoxicity, less side effects, convenience of storage, transportation, caplendus, taking along and production, and some characteristics, such as security, utility, manipulation and stabilization. Based on the theories of Traditional Chinese Medicine, active parts of Lumbricus, Radix Scutellaria, Radix Glycyrrhizae, Gardenia Panax notoginseng are extracted to constitute modern preparation respectively, includes Longqincao spray , buccal tablets and Tongluojiunao injection , micro emulsion by mounth. Their ingredients is primitively definite, and drug action is certain, and quality can control through the research of pharmacy, pharmacodynamics as well as mechanism of action. We will determine reasonable preparation technology, establish scientific quality control standard, also increase bioavailability and promote curative effect by administration through oral or nasal mucous membrane(Longqincao soray, buccal tablets) and per os nanometer-scaled micro emulsion (Tongluojiunao micro emulsion by mounth). Methods:This research includes studies on preparation technolog, quality standard, stability, archeopharmacodynamics, pharmacokinetics, and toxicology of Longqincao spray and buccal tablets.The studies of preparation technolog, quality standard, stability ,and bioavailability of Tongluojiunao microemulsion by mouth.The part of Longqincao preparation: The prescription is made of Lumbricus, Radix Scutellaria, Radix Glycyrrhizae.The optimal prescription is obtained by combining flu and respiratory infection feature, abiding by compatibility method of Chinese midcine, filting by pharmacology .The group is made high performance preparation of active parts,and through oral and nasal membrana mucosa administration.It can clearing lung-heat to ease the throat, removing toxic purging heat.1.The preparation technolog of Longqincao spray and buccal tablets: Active part of lumbricus was extracted by biochemical technology. According to requirements on extractive of Radix Scutellariae in primary part of Pharmacopoeia of the People's Republic of China (version 2005) and requirements of Ammonium Radix Glycyrrhizae in State Drug Standard (WS-10001(HD1269)-2002), content of baicalin and ammonium glycyrrhizinate was controlled with HPLC; According to preparation requirement of spray and buccal tablets, parameters of manufacture process were ascertained and preparation craft was established.2.Quality standard of Longqincao spray and buccal tablets: Radix Scutellariae. Radix...