The Clinical Research Of The Activating Blood Circulation To Dissipate Blood Stasis Method Reversing The Expression Of P-gp And BCRP Who Are The Type Of Blood-stasis Obstructing In The Interior Breast Cancer

[Objective] This research plans to observe the contribution that Taohongsiwu Decoction how to play on the Chem curative effect of the patient who is the type of blood-stasis obstructing in the interior and to approache the mechanism of action. By contrasting the change of the tumor magnitude between the treated groups and the control group observes the clinic curative effec of Taohongsiwu Decoction and Chuanxiongzine combined chemotherapy to the breast cancer' type of blood-stasis obstructing in the interior. By detecting the change of the positive expression of P—gp and BCRP with immunohistochemical method between three groups, evaluates the reveral effect to the Chem of the drug for invigorating blood circulation and eliminating stasis objectivly.[Methods] 60 cases who are consistent with the norm of internalization were divided into 3 groups(the group of Taohongsiwu Decoction; group of Chuanxiongzine Inj; group of Chem) by RTC. The texture which were obtained by bodkin puncturing were determined the expression of P—gp and BCRP by pathoscopy of immunohistochemical method. After 3 course of treatment, all the cases were assessed the curative effect : CR; PR; SD; PD and were operated the improved radical correction of breast cancer. The texture were determined the expression of P—gp and BCRP by pathoscopy of immunohistochemical method again. Contrast the change of the two expression of P—gp and BCRP by statistical analysis, and evaluate the effect of the drug for invigorating blood circulation and eliminating stasis to revers the MDR. All the data were analysised by SPSS13.0. [Results] There are 56 cases which are put into our research practically , and 4 cases fell off in the 60 cases. There is comparability and is not statistical difference at the positive expression of P—gp and BCRP prior treatment between the 3 groups(P>0.05). However; after 3 course of treatment, the positive expression of P—gp and BCRP of the Chem group step up, simultaneously, the positive expression of P—gp and BCRP of the Treated group cut down in varying degree. There is statistical difference at clinic curative effect by observing the magnitude of the swelling between the 3 groups (P <0.05).[Conclusion] By contrasting the treated groups with the control group, the difference between the three groups' result has statistical significance. The curative effect of the treated groups surpasses the control group. Comparing the ascensus of proteinic expression of the control groups, the descent of proteinic expression of the treated groups has distinction. The treated groups can reverse positive expression of P—gp and BCRP. Traditional Chinese medicine in coordination with Chem could reverse MDR efficiently, increases the result of Chem, improve the therapeutic effect. Tt can extend all the patient who is the type of blood-stasis obstructing in the interior. Simultaneously,this research can offer foundation in order to the further study of the reversal of MDR more deeply.