Liquid Ventilation In The Treatment Of Cardiopulmonary Bypass Lung Injury After Experimental Research

1. Partial liquid ventilation reduces pulmonary inflammatory reaction in piglets after cardiopulmonary bypassBackground: Cardiopulmonary bypass causes pulmonary inflammatory reaction. Partial liquid ventilation has been developed as an alternative ventilatory strategy for acute lung injury. The aim of this study is to investigate the effect of partial liquid ventilation on pulmonary inflammatory reaction in piglets after cardiopulmonary bypass. Methods: After general anesthesia with endotracheal intubation and establishment of CPB, each piglet was cooled to 28℃, exposed to 60 minutes of cardiac arrest, rewarmed to 37℃ and removed from CPB. 12 piglets were randomly treated with conventional gas ventilation (control group) or partial liquid ventilation (study group) for 240 minutes. Samples for blood gas analysis were collected before and at 30-minute interval after cardiopulmonary bypass. The histologic examination was performed. The levels of interleukin-6, interleukin-8, and myeloperoxidase in bronchoalveolar lavage and plasma were analysed. Results: The dynamic lung compliance was significantly increased in partial liquid ventilation group (p <0.01). The concentrations of interleukin-6, interleukin-8, myeloperoxidase in bronchoalveolar lavage was significantly lower in the study group (IL-6, 22.80±7.02 vs 81.32±15.23 pg/ml; p<0.01; IL-8, 299.37±99.32 vs 551.63±119.34 pg/ml; p<0.01; MPO,...