Partial Liquid Ventilation In The Therapy Of Acute Respiratory Distress Syndrome Induced By I.V.Injection Of Oleic Acid In Dogs

Objective The aim of this study was to determine the effectsof partial liquid ventilation(PLV) using a perfluorocarbon(PFC)on gas exchange, lung compliance and lung inflammatory responsein a canine acute respiratory distress syndrome model.Methods Acute respiratory distress syndrome was induced in 12dogs weighing 10.80±0.87 ㎏by i.v. injections of oleicacid .Thereafter,the animals were randomized to receive eitherpartial liquid ventilation(PFC group,n=6) or conventionalmechanical ventilation (control group,n=6) at a fractionalconcentration of inspired O2 of 1.0,a fixed rate of 16breath/min,tidal volume (VT)(10ml/kg)and a PEEP of 5cmH2O whichis added only after acute respiratory distress syndrome isinduced.Measurements were made every 30min till 150min.Then thelungs were removed for histologic analysis.Results When compared with control animals,there wassignificant improvement in PaO2 and less lung injury with lessinflammatory cell infiltration.There was no significantdifference in parameters of lung compliance and hemodynamicsbetween both groups.Conclusions We conclude that PLV with perfluorocarbon improvesgas exchange and decreases lung inflammatory response withoutnegative hemodynamics but has no significant influence on lungmechanics.