Study Of The Molecular Genetics Of Type 2 Diabetes In Han Population In Beijing

Backgroud:Diabetes is a common chronic disease with a feature of glycometabolism disorder, the bulk of the total (>90%) are type 2 diabetes (T2DM). At present, in academic circles the fundamental commons recognize about T2DM is that it is a complex character polygenic disease which is induced by multi-heredity and environment factors. Electing candidate gene to carry out association analysis is one of the most utilized strategies about the etiology of T2DM. Insulin resistance (IR) and islet β cell functional deficit are two primary causes of T2DM. Obesity is one of the most important causes of IR, so genes about obesity and insulin secretion have been investigated as a cardinal source of candidate genes for T2DM. In particular, suggestive or significant association has been detected in some studies between the adipose-derived cytokine adiponectin, adipose tissue transcription factor peroxisome proliferator-activated receptor gamma2 (PPARγ2), and mitochondrial membrane proton transporter uncoupling protein 2 (UCP2) gene with T2DM.Although variants in these genes have shown association with T2DM in some studies, these associations are often not reproducible in studies of other populations. These inconsistent results from previous association studies of various candidate genes with T2DM may have resulted from differences in the polymorphisms frequencies that construct the specific genetic architecture of different ethic population. As a consequence, the relative contribution of any given variant varies from the different studied population. One gene may be responsible for the disorder in one population, but not necessarily inn another population. Based on this, reproduction of the finding in a different ethnic population is considered to be important.Genotyping of multiple diallelic sites, especially dense single nucleotide polymorphism (SNP) sites, is now available for genetic studies of human disease. It is more powerful to focus on the transmission of multilocus haplotypes, as opposed to alleles at individual loci. Therefore, haplotype analysis is mandatory in this regard and...