Obstructive Sleep Apnea Syndrome Led To Study The Biochemical Mechanisms Of Memory Ability And Treatment Of Clinical And Basic Research

Part OneInsulin-like Growth Factor-I and Cognitive Function in Patients with Obstructive Sleep Apnea SyndromeBackground: Cognitive impairments are the major neurocognitive manifestation of obstructive sleep apnea syndrome (OSAS). The available correlational studies of physiological disturbances during sleep and cognitive impairments in human further suggest that reductions in cognitive function are primarily attributable to the chronic episodic hypoxia (EHYP). However, the role played by EHYP in the cognitive dysfunction of OSAS is not very clear. Recently, the effects of insulin-like growth factor-I (IGF-I) on learning and memory have been concerned. Several previous studies have suggested that serum IGF-I levels decreased significantly in children with OSAS, but limited data are available about the relationship of cognitive dysfunction with circulating IGF-I levels in patients with OSAS.