Soluble Stent Transfected With C-myc Antisense Oligonucleotides The Prevention Of Vein Graft Restenosis

Objectives:Saphenous vein is the most popular vascular graft in CABG, but vein graft restenosis is still a problem unsolved. The mechanism is thought to be very complex. Vein graft failure maybe the result of thrombosis formation, neointima hyperplasia and vascular remodeling. Early vein graft are attributed to thrombosis, intima hyperplasia and vascular remodeling play key roles in the late vein failure. Intima thickening is resulting from excess accumulation of vascular smooth muscle cell (VSMCs) proliferation and migration, extracellular matrix deposition. Proto-oncogene plays key roles in VSMCs proliferation. A rabbit model of common carotid arteries grafted by external jugular veins used, this study focus on the proto-oncogene c-myc gene, vein grafts are transferred by c-myc antisense oligodeoxynucleotides(ODN) carried by soluble stent, in order to investigate the effect of c-myc gene in vein graft stenosis, assess the possibility of transferring antisense...