Aortic Stenosis Interventional Treatment And Related Experimental Research

Part one: Interventional treatment for congenital coarctation of aorta Objective To evaluate the short and long-term efficacy of congenital coarctation of aorta treated with interventional therapy including percutaneous transluminal angioplasty (PTA) and implantation of stents. Methods 10 cases suffered from congenital coartation of aorta including 6 cases afflicted with other cardiac anomalies underwent interventional therapy. 7 cases underwent PTA. 3 cases underwent PTA and implantation of stents. All the patients were examined with follow-up data from 1-82 months. Results The universal successful rate of the 10 cases with coarctation of aorta was 100%. Immediate success with PTA and stents implantation was achieved in all patients. PTA and stents implantation produced a significant decreae in coarctation gradients from (61.00±13.97) mm Hg (1 mm Hg = 0.133 k Pa) to (16.70±7.12) mm Hg (P<0.01) and a significant increase in the coarctation diameters from (3.73 ± 1.04) mm to (11.98±2.42) mm (P<0.01).The results of follow-up data indicated the therapy efficacy of 9 cases was stable and there was no relapse, but 1 case appeared symptomatic hypertension 3 years after PTA and relapsed 3 months after implantation of stent. Conclusion Interventional therapy including PTA and implantation of stents for coarctation of aorta is safe and effective. It is worthy of gradual use in clinic.Part two: Endovascular stents for stenosis of aortaobjective To evaluate efficacy of stenosis of aorta treated with implantation of endvascular stents. Methods 14 cases suffered from stenosis of aorta including 10 with Takayasu's arteritis, 1 with athersclerosis and 3 with coarctation of aorta, underwent implantation of endovascular stents. All the patients were examined with follow-up data from 10-102 months. Results The universal successful rate of the 14 cases with stenosis of aorta was 100%. Immediate success after implantation of stents was achieved in all patients. Stents implantation produced a significant decreae in the systolic pressure gradients from (61.00±13.97) mm Hg to...