Regulation Of Nnos In The Adult Hippocampal Dentate Gyrus Neurogenesis And Its Molecular Mechanism

Recently, a series of experiments suggested that ongoing neurogenesis in the dentate gyrus not only occurred in the normal adult mammalian brains, but also was enhanced by many physiological activities and pathological events. These findings provide possibility and feasibility for neuronal self-repair after ischemia insult by regulating some ischemia-related molecular. Therefore, discovering the molecular mechanism underlying neurogenesis will help us improve the therapy strategies in stroke and other neurodegeneration diseases and will help us clear the right intervention link of the drug and find new drug target. However, until now, the research about neurogenesis still stayed in the stage of finding phenomena, the mechanism underlies it was little known.As a new signal molecular in the CNS, NO plays an important role in adult neurogenesis in the brain. NO and NOS regulation of neurogenesis has recently became the hot issue. However, the results about the regulation of neurogenesis by NO/NOS are conflicting. Recently two studies show that nNOS-derived NO exerts a negative control on the neurogenesis in the adult SVZ. The two studies however, observed conflicting roles of nNOS-derived NO in the DG neurogenesis.