.hpv11-e6/e7 With People Of Ifn��-2b Fusion Gene Expression Plasmid, Expression And Immunological Study

Human papillomavirus(HPV) can cause many kinds of benign and malignant diseases in human beings.According to whether inducing malignancy or not,HPVs were divided into low-risk types and high-risk types.HPV6,11 belonging to low-risks,were the main types which cause condyloma acuminatum(CA).Morbidity of CA is increasing in the world year by year and CA has become one of the most common sexually transmitted disease(STD).In our country,it becomes the second common STD,in the west,it has jumped to the top of the list and severely threatened the physical and mental health of patients.At present,there is no specific treatment for CA.In addition,recurrence rate of post-treatment is very high,which becomes a clinically formidable problem.Up to now,HPV vaccine development and immunological study have been complicated by the lack of animal models for HPV infections and the difficulty in propagating HPVs in cultures according to the tradition. Fortunately,with the development of molecular biology and gene engineering,people began to prepare DNA vaccines,protein vaccines and DC vaccines,etc.using gene cloning .People attached more importance to DNA vaccines because their advantages are as follows: Its immunological response lasts longer and immunological result is reliable; DNA vaccines can induce humoral immunity and cellular immunity simultaneously;the vector part of DNA vaccines has no immunogenicity...