Gax Gene Inhibits Vascular Adventitia Into The Experimental Study Of The Fiber Cell Proliferation

BackgroudThere are a lot of evidences which indicate that vascular endothelial cells(VEC), vascular smooth muscle cell(VSMC), adventitial fibroblasts (AF) and intercellular matrix are all involved in vascular remodeling. In the past, the function of VEC and VSMC was emphasized in vascular remodeling. Recent studies, however, have revealed that AF as the major cell component in vascular adventiua, is not static and passive but mobile and active, which can respond to diverse stimulations and plays an important role in neointima proliferation, cell migration, phenotype transformation, adhesion, cytokine excretion and epimatrix formation. This process is regarded as the important mechanism of vascular remodeling. Recently, it is found that there are affluent progenitor cell in vascular adventitia, which can differentiate into VSMC in vivo and in vitro. Though some negative views are hold on this theory, on the basis of these data showing AF plays an important role in vascular remodeling. Though people carried out a lot of experiments and made some progress on AF biological mechanism, AF's much mechanism of proliferation, immigration and adhesion is unclear; TGF-β1 is viewed as the most important factor which affects AF bioactivities, however its specific mechanism of action on AF is also unclear.In the process of vascular remodeling, the effects of growth factors (such as VEGF and FGF) and their signal transduction pathway on vascular cell proliferation have been investigated intensively. However the study of nuclear factors on regulating vascular cell bioactivities has been rarely reported. The regulation at transcriptional level is the most important step for eukaryotic genes expression, which is the core of many signal transductionn pathway of cell proliferation. Gax gene is a recently found nuclear transcription factor, which plays a significant role in regulating henogenesis,...