| The pharmacokinetics of the prescription of the traditional Chinese medicine (PPTCM) has been developing to aim directly to study on the pharmacokinetics of the traditional Chinese materials and its constitutional prescriptions.on the basis of pharmacokinetic theories. It occurs to us that there are four challenge problems to study on the PPTCM, with the present pharmacokinetic methods that is established on compartmental models, parameter analyses of center compartment and satisfied with single compound. The four problems are: ①how to establish the mathematic models satisfied with the multicomponent system; ② how to determinate simultaneously multicomponents; ③how to eliminate the interferences form blood ingredients:④ how to deal with information of the PPTCM. For that the theoretical and experimental studies on PPTCM has been carried out.Theoretically:1.To have elucidated and establish the mathemathic models of the PPTCM: Total Quantum Statistic Moment(TQSM).2.To have established the Total Quantum Statistic Moment Analyses of the fingerprint(TQSMAF) that has of qualitative and quantitative immediate analyses, in combination of the TQSM with fingerprint. The TQSMAF, to overcome shortcoming of similarity analyses that can not be calculated the peak area with addition and substraction, independs on the analyses of character peaks to be transformed multidimension vectors with peak vs. peaks. It has been considered the fingerprint as probability density ruction added by multicomponent Gauss curves to be dealt with the curve characters of the fingerprint with statistics, as a result that AUCT can be applied to quantitative analyses, whereas AUCPWT, MIVVT,VIVVT can be used to qualitative analyses.3 To have elucidated and establish the 2-Dimension Vector Total Quantum Statistic Moment(2-DVTQSM) models of the PPTCM, in combination of fingerprint with pharmacokinetics; To obtain the parameter expressions of 2-dimension vectors;To describe the curve character with AUCT, (λ|-)T,i=2,Ε2Tλ,i=2(VIVVT), MRTt, Ε2Tt,i=2(VRTT) .4. To have elucidated out the calculation formulae for 2-Dimension Vector Total Quantum Statistic Moment models ,in combination with pharmacokinetic experiment that can be calculated by ourselves editing programming with EXCEL software ; To calculate the ratio between the area under the curve with trapezoid and integration by ourselves editing programs with Visual basic software to determinate 9 as minimum sampling experiment point.Experimentally:5. To have studied on the pharmacokinetic parameters of astragalalV, peoniflorin, amygdaloside, tetramethylpyrazine ferulaic acid in the Buyanghuanwu Deco-ction(BYHWD) and available fractions with present pharmacokinetics, to deal with the TQSM parameters of the five available ingredients that results show AUC as 613.5 mg·min·mL-1; MRT as 135.1 min; VRT as 2.813×105 min2; CL as 0.01007 mL·min-1·kg-1. The results testified the TQSM could conform single ingredient parameters to bring about total pharmacokinetic parameters, to explain the...
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