The Study Of The Morphology Of The Nervous System Of Immune Stimulation

There is a growing body of evidence for bidirectional regulation between the nervous system and the immune system. According to the current opinion, the centrol nervous system can "feel" the peripheral immune signals through cytokines or other products released by activated immune cells during immune response, and exert regulaory effects through neuroendocrine system and autonomic nervous system.By using immunohistochemical method, the present studies investigated several issues related to the neuro-immune circuts, namely morphological changes of innervation of the spleen during immune response; activation of corticotropin-releasing factor (CRF) containing neurons in the hypothalamus by tumor necrosis factor and interleukin-6; the relationship between the posterior-pituitary hormone-oxytocin, and immunoregultion.The present study consists of the following three parts:1. distribution and nature of the growth associate protein (GAP-43) containing nerve fibers in the spleen of devoloping and adult mouse, and the morphologic changes of the nerve fibers during immune response.In the spleen of the adult mouse, GAP-43-like immunoreactive (LI) fibers were extensively distributed not only in association with vascular plexuses, but also in the parenchyma of the spleen, .especially in the inner layer of the peripheral arterial Lymph Sheath (PALS) of the white pulps, where T lymph...