Experimental Study Of Blood Lead Levels Of Children With Adhd And Drug Prevention And Treatment Of Lead Poisoning

Lead is an important environmental pollutant, as well as a neurotoxicant. Lead exposure impairs nervous system and can cause cognitive deficits, behavior and psychological disorders in children. One can be diagnosed as lead poisoning when his blood lead level exceeding 100 μg/L. According to this criterian, about 10-30% of child population in China was stricken by lead poisoning, so lead contamination is still a serious and general question. The present study focused on relation of the blood lead levels and the risk for attention-deficit hyperactivity disorder (ADHD), and the effects of nicotine (NIC) and α-lipoic acid (LA) on the lead-induced long term potentiation (LTP) impairment.1. Blood lead levels and the risk for attention-deficit hyperactivity disorder in Chinese childrenAttention-deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder, which is characterized by the inability to marshal and sustain attention, modulate activity level, and moderate impulsive actions. Prevalence of ADHD in children has been reported to be between 3-7.5% in recent studies. Both genetic and environmental factors are thought to influence the etiology of ADHD. To address the putative association between ADHD and blood lead levels, a retrospective, hospital-based, case-control study was conducted with 1050 ADHD cases and 800 non-ADHD controls of both genders aged between 6 and 12 years old from two pediatric clinics at the Anhui Provincial Children Hospital and the Institute of Anhui traditional Chinese Medicine in Anhui Province, P.R China.In the present study, we performed an unconditional multivariate logistic regression analysis, trying to evaluate predicting risk for ADHD among the blood Pb levels and other known risk factors including the child sex, maternal characteristics of pregnancy and delivery, maternal and paternal education etc. The backward stepwise logistic regression analysis based on the maximum partial likelihood estimates was performed to get the final best-fit model, in which only sex, maternal and paternal education and blood lead level were identified as risk predictors. Secondly, we set 100μg/L-the recommended blood Pb level for pediatric populations, as a higher quantile; and set 50 μg/L as lower quantile. Then performed a logistic regression analysis of ADHD in relation to blood lead level in which blood lead level was treated as as a categorical...