Study Of Botulinum Toxin Type A Treatment Of Focal Muscle Dystonia And Muscle Spasm

(PART ONE)The treatment of focal dystonia and muscle spasm with Botox and CBTX-A.Although it is not a life-threatening disease, focal dystonia and muscle spasm can be devastating to the lives of the individuals affected. Most patients are embarrassed by the odd postures and movements their condition causes. It is not very difficult for an experienced neurologist to reach the diagnosis simply by observation, because the movements and postures are so distinctive. But the management of focal dystonia and muscle spasm represents one of the most difficult problems in clinical practice. Recently, type A botulinum toxin(BTX-A), a powerful presynaptically active neuromuscular blocking agent, represents a major breakthrough in the treatment of focal dystonia, and has been used successfully in the treatment of a variety of spasmodic disorders.We have been collecting the relevant data about BTX in the treatment of neurological disorders since 1992. On the basis of reviewing these data, we treated focal dystonia and hemifacial spasm with Botox and observed satisfying results. A Chinese type A botulinum toxin(CBTX-A), made by Lanzhou Biological Products Institute, had been approved by the Ministry of Health in China to be produced attemptably for the clinical use since October 1993.In this report, we describe the results of BTX-A(Botox and CBTX-A) treatment, a prospective open study, in 785 patients with focal dystonia and other neurological disorders characterized by involuntary or abnormal muscle contractions.Objective To confirm and compare the therapeutic efficacies of CBTX-A and Botox for focal dystonia and other neurological disorders characterized by involuntary or abnormal muscle contractions.MethodsPatients. About ten hundred patients with a variety of movement...