Human Papillomavirus (hpv), The Original Cancer, Tumor Suppressor Gene In Cervical Cancer Cell And Molecular Biology Research

The squamous cell carcinoma of uterine cervix ( cervical cancer)is one of the most common cancers in adult females. At present most scholars put the main work on the human papillomaviruses (HPVs) in the etiology and carcinogenesis of cervical cancer. There are approximately 68 types of HPVs which have now been characterized.As known up-to-date 27 of these HPVs are associated with genital lesions and these HPVs can be further classified as either "high risk" or "low risk" based on whether or not the genital tract lesions with which these HPVs are associated have a risk for malignant progress ion.The high risk viruses such as HFV-16 and HPV-18 are easily detected in cervical carcinoma,cervical intraepithelial neoplasia (CIN) and cervical cancer cell lines. Recent years,more and more evidence have demonstrated that HPV (especially HFV-16 and HPV-18) is an important carcinogenic factor in cervical carcinogenesis. Multi—factor and multistep hypothesis of carcinogenesis were proposed on the basis of a wide spectrum of investigation to elucidate the etiology of cervical carcinoma. Although there were reports at home and abroad on HPVs,oncogene(C-myc,H—ras) and tumor suppresor genes respectively in studying the etiology of cervical carcinoma, these reports were usually in consideration on single factor. There are no report on the conbination of three factors into consideration in the same...