Five dirivatives of Schisanhenol(I) were prepared.One of them, Schisanhenol succinic monoeater(A1) was found to inhibit lipid peroxidation activityby pharmacological screening.The erythro-form(C5) and threo-form(C7) of dihydroguararetic acid dimethyl ether were synthesized. The intermediates, erythro-form and threo-form of 1,4-diketone(C3) and their reduced productserythro-C6 and threo-C6 were obtained. The conditionsfor the reduction and oxidation of 1,4-diketones and 1,4-diols respectively, have kept the stereo-configuration unchanged. The structure of a new lignan E1 was elucidated using the above result.Aluminium iodide was used as the demethylating agent of deoxyschisandrin(B1). The demethylation occurred at hindered -positions of thebiphenyl system.
|