| DHEA is an adrenal 17-ketosteroid that is biosynthetic precursor to testosterone and 17-beta estradiol, which is the most abundant adrenal steroid hormone in human. Interestingly, DHEA and its precursor DHEA-sulphate, are decline gradually from 25 years old, reaching 15-20% of the maximum in individuals over the age of 70. The tumor chemopreventive activities involving anti-promotion, anti-mutagenic effects of DHEA and its mechanisms of action were studied in this paper. Furthermore, its anti-oxidative and immune modulating effects were also investigated. The main results are summarized as following:(1) Effects of DHEA on Cancer ChemopreventionBy using two stage chemical transformation model of Balb/3T3 cells in vitro, we have demonstrated that DHEA 10-5 mol/L could significantly inhibited DMBA and TPA induced malignant transformation by 69.0%. In DMBA-induced rat mammary tumor model, the rats were orally administrated DHEA daily for 2 weeks...
|
PDF Full Text Request