EGFR Family Expression In Laryngeal Squamous Cell Carcinoma Collaborative Expression And Of EGFR In CNo Of The Significance

Background : Laryngeal cancer is the common malignant tumor in otolaryngology. Laryngeal squamous cell carcinomas comprise the vast majority (96%) of laryngeal malignancies. At present, the incidence of laryngeal cancer is increasing obviously. It is not only because of the improvement of clinical diagnostic technique, average life augment, but also have the possibility of aggravation of air pollution, smoking, and some long term occupational contacting with carcinogens. This is consistent with the phenomena of the higher incidence of laryngeal cancer in cities than in countryside, in heavy industry cities than in light industry cities.Laryngeal cancer comprise of 5.7-7.6 percent of all malignancies, 7.9-35 percent of otorhinolaryngologic malignancies. Till now, the molecular pathogenesis of carcinomas has been not clear. The majority of researchers considered that the occurrence of tumor was a long term, multiple factors, and grading process. Tumor malignant transformation was not caused by a single genetic alteration, but multiple genetic alterations,. Laryngeal cancer was closely associated with activation of proto-oncogene, inactivation of anti-oncogene and factors related to apoptosis. Carcinomas tend to be considered as a genetic disease. It exists proto-oncogene in eukaryotic cells. As a part of human hereditary code, proto-oncogene encodes specific enzymes, membrane receptors, and growth factors correlated with cellular growth and development. The expressive level of proto-oncogene was low or negative in normal condition. Under the influence of carcinogens, proto-oncogene activation and point...