| Objective: To observe the treatment of BPH of Yishentong capsule and the clinical effect on urodynamic indicators such as the impact of exploration can be integrated form of regulation and detrusor prostate, bladder neck sphincter function of the drug, and through animal testing, of Yishentong Arguably the GuangWangBuLiuXing (Ficus Pumila L) to alcohol extracts of rat model of chronic bladder neck obstruction apoptosis smooth muscle cells of rats and chronic bladder neck obstruction model detrusor semi-quantitative reverse transcription-polymerase chain reaction (RT - PCR) testing of the smooth muscle myosin expression of on-line-do not stay in the influence of alcohol extract of molecular pathology smooth muscle cells to change the role and significance, its treatment of BPH speculate the mechanism for application and further development of the motherland Traditional Chinese medicine in the provision of modern scientific theory.Methods: The subjects from clinical studies and animal experiments composed of two parts. Clinical studies of the use of randomized controlled forward-looking approach to non-finasteride for the control group, treatment and control groups before and after treatment self-control and the control group study. Study from the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine surgery department and andrology clinics and patients, a total of 60 cases, two groups of patients with general information and laboratory analysis of statistical indicators, as no significant difference, comparable, and were randomly divided into For the treatment group of 40 patients, 20 cases of the control group. The treatment group to Yishentong capsule, four capsule each, tid, the control group to finasteride, (5 mg), a day, a total of three months of treatment. Observation of the two groups before and after the treatment I-PSS score, prostate volume, bladder residual urine, the largest flow rate and detrusor contraction, and other indicators. Some animal experiments choose general-level SD 45 male lab rats were divided into the blank group, the model group, and the experimental group of 15 each. Reference to literature produced in the bladder neck obstruction model, the application of Chinese Medicine call GuangWangBuLiuXing (Ficus Pumila L)liquid (main medicine of Yishentong capsule). Blank group model and the administration gavage, the model of model not to the experimental group of modeling and administration. GuangWangBuLiuXing (Ficus Pumila L) observed to remain alcohol extract of the rat model of chronic bladder neck obstruction and detrusor contraction organizations and the morphology of apoptosis detrusor smooth muscle cells seizure (TUNEL). Spss11.0 package with all the data for statistical analysis. Results: The clinical study: the comprehensive effect of the treatment group compared with the control group a significant difference (P<0.05). Compared with before treatment, the treatment group and control group in the I-PSS score, the largest flow rate, respectively, P <0.01 and P <0.05, both significant difference, while the former more visible; residual urine in the bladder and bladder Detrusor contraction, the treatment group for the P<0.05, P<0.01, a significant difference, but no significant difference in the control group (P>0.05); in prostate volume, both groups with no significant difference in treatment (P>0.05). Compared with the control group, treatment group I-PSS score, bladder residual urine, the largest flow rate, the detrusor contraction in both statistical difference (P<0.05); prostate volume of the two groups had no statistical change Differences (P>0.05). Animal experiments: (1) under the number of blank group apoptosis of 15.5 percent, the model number of apoptosis 50.2 percent, the experimental group apoptosis number was 30.4 percent, compared to the group were statistically significant ( p<0.05). (2) electrophoretic analysis of the results of the blank group with the most clarity, the model weakest, and between the experimental group between the two.Conclusion: The subject of Yishen capsule treatment of BPH clinical efficacy than the control group and to improve the I-PSS score, bladder residual urine, the largest flow rate and detrusor contraction has obvious advantages, benefits to speculate Kidney-treatment of BPH, the existence of the multi-faceted and integrated mechanism, both to improve the symptoms of chronic bladder neck obstruction can also improve the detrusor function, for the treatment of BPH provide a new way of thinking. GuangWangBuLiuXing(Ficus Pumila L) for animal experiments suggested that alcohol does not stay in line extract can inhibit the rat model of chronic bladder neck obstruction detrusor smooth muscle apoptosis and degraded state of the smooth muscle cells, thereby improving the detrusor function.
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