Contemporary Annotation The Concept Of Innateness And It's Dependablity With Stroke Onset

Innateness(禀赋) is a special concept of Traditional Chinese Medicine(TCM),which relative content runs through many taches of theory and practise,with important academic significance and practice value. However,the concept and reliable definition of Innateness could not be reported till now.Along with the era of life science century,modern medical pattern is changing from biomedicine to society-biology-psychology medical pattern,the research on individual of human being is facing a new times.The connotation of Innateness concept is abundant and its extension is comprehensive.Today,when outer factors such as environment and life style are attached importance increasingly, the theory of Innateness has a predominance not edged out by the concept of heredity and constitution,which may be a new interject point of life research.So whole connotation of the concept of Innateness,lucubration the relation among health and disease and the physiology,pathology, diagnosis,prevention and treatment on Innateness would have a important signification on construction of frame of Innateness theory,promotion of innovation of basical theory of TCM,exploring arcanum of anthropic life,direction of clinical practice.Stroke is a clinically familiar,acute and severe disease,threatening on human health with the characteristics of high incidence,high deformity, high rate of death and high rate of recrudesce burdening much on society and family.TCM has special superiority on prevention and treatment of Stroke,then if theory of TCM Innateness is used in the research of Stroke, it will help to development of Stroke etiology,deepeness of understanding Stroke syndrome,leading to the individualization of Stroke' s diagnosis, treatment and prevention.1.Aim1.1 By theoretical research,we will annotate wholely TCM concept of Innateness,definitude its characteristic,effective factor and regulator, and so on.,elucidate the applied value of Innateness in clinical practice of TCM.In the same time,we will definitude relation and difference among Innateness and habitus,Innateness and heredity.Then we will get mostly integrity and precise TCM concept of Innateness.1.2 In application research,we took stroke as a model,definitude the relation between accidence and Stroke patients' five-state character characteristic and heredity factor,explore the relation between Innateness and stroke,then put forward the basic thought of Stroke' s prevention and treatment in the point of view of Innateness,which will base scientific evidence on "Prevention of disease" and individualization therapy of Stroke.1.3 Summarization above result of research makes basement for the research of individual Innateness characteristic in the point of view of psychology, eugenics,molecular heredity,and further research of the relation between Innateness and human body from the lays of physiology,pathology, diagnosis,prevention and treatment on Innateness.2.Methods2.1 Theoretic research methodsBy theoretical research,we use TCM philology research method,and systemitically clear up the content about Innateness in TCM conference of past dynasties.We summarized up the detail about Innateness including the physiology,pathology,diagnosis,prevention and treatment in TCM. Linked with theoretical knowledgement such as modern heredity,psychology, some important content and signification of shape and spirit in TCM concept of Innateness will be revealed.2.2 Application research methodsIn application research,we used the clinical epidemiological methods of case control research by Test table of five-state character in TCM and Questionary of the history of stroke of the first-degree relatives, explore the relation between Innateness and Stroke,in the two layers of born manifestation and innate essential of Innateness.The two steps will take up in the same time.The test table of five-state character is based abstractly on inner Canon of Yellow Emperor theory of five-state Yin & Yang,and consults true characteristic of modern person.The table maps out national whole model,with high reliability and validity.The table divids human' s character into Taiyang,Shaoyang,Taiyin,Shaoyin, balanced Yin & Yang.On this table,testers trained by researcher measure every object.If research object can not know word or see clearly,this table may be read for him/her.The self-designed,uniform Questionary of the history of stroke of the first-degree relatives is questionnaired direct question on all research objetct,which include age,sex, nationality,professional,family occurring of cerebral infarction and so on.In the questionary,genealogy investigation including mainly the first-degree relatives and spouse involves age,age of accidence,history of cerebral infarction and so on.In the research of the relation between five-state character and accidence of Stroke,the control group is general national normal model.In the research of the history of stroke of the first-degree relatives,control group are the patients of nephritis in the corresponding period in urologic medicine ward in the same hospital. According to the obtained data,we analysis the Innateness characteristic, ie.five-state character of Stroke patients.We calculate segregation ratio of Stroke by the method of Li-Mantel-Gart and its heredity degree by the method of Falconer.We also calculate the correlation degree(odds ratio,OR) of the history of stroke of the first-degree relatives and the cerebral infarction.Then in the five-state character characteristic and heredity,we explore the relation between Innateness and stroke.3.Results3.1 The comparison of accident rate of cerebral infarction patients' the first-degree relatives and different sex with that of control group:The accident rate of cerebral infarction proband in the first-degree relatives is 6.58%,comparing with that of control group(1.74%), significantly difference(χ~2=28.664,P=0.000).The risk of stroke of person who has the history of stroke of the first-degree relatives is 3.97 times of the person who has no the history of stroke of the first-degree relatives.In the investigation on 100 pairs proband spouse,we find that accident rate of case group spouse is 4%(4/100),and that of control group is 2%(2/100),which that of case group is higher than that of control group,without significant difference(χ~2=0.687,P=0.407)。3.2 Segregation ratio of cerebral infarction:The accident research on 100 cases of probands' fellowmen(inciuding the proband) on cerebral infarction shows that segregation ratio of cerebral infarction P=0.1398, segregation ratio Variance:Sp~2=0.00029,Standard error:SE(P)=0.01702, 95%CI:0.1064-0.1732。3.3 Heredity ratio of cerebral infarction:Heredity ratio of cerebral infarction patients' first-degree relatives is 47.34%±4.46%.With a view to the effect factor of accidence of cerebral infarction by sex,we analysis the first-degree relatives in delamination of sex,then that of male among the first-degree relatives show higher than that of female. Above all,in the period of accident of cerebral infarction,heredity factor takes a certain action,especially more marked correlation in male.3.4 Comparison of five-state character score between cerebral infarction group and control group(national nomal model):Comparing with control group,Taiyang personality dimensionality score and Shaoyang personality dimensionality score of case group is lower markedly than that of control group(P＜0.01).The score of personality dimensionality in balanced Yin & Yang in case group is markedly lower than control group (P＜0.05).Dimensionality score of Shaoyin personality in case group is markedly higher than control group(P＜0.05).The score of Taiyin personality dimensionality in case group is markedly higher than that of control group(P＜0.01)。4.Conclusions4.1 Innateness is a individual' s compositive and rather steady characteristic in configuration,physical function,psychological status and metabolism based on innate heredity and iner and outer enviroment' s effect.It come out before bore and is effected by inner and outer environment in the period of fetus or pregnancy.4.2 On point of view of modern biology and heredity,the concept of TCM Innateness have the difference of narrow sense and broad sense,which narrow sense is heredity information,and broad one is all unborn information including heredity and embryogenesis information.For TCM, broad sense of Innateness takes more.4.3 Innate substance of Innateness includes heredity and embryogenesis information,and the born manifestation of Innateness includes constitution,psychology,which the innate essential determines the born manifestation.4.4 Innateness has congenital,individual,regional,ethnical and adjustable characteristic.The congenital one is the most basic characteristic.The characteristic of Innateness is the ultimate products of interaction between heredity and the environmental condition.Any changes in these two conditions can result in change in some characteristics of Innateness,which may lead to regulation of Innateness. 4.5 The history of stroke of the first-degree relatives has dependablity with the onset of cerebral infarction.4.6 According to the classification of five-state person in book of Lingshu Tongtian,character characteristic of cerebral infarction patient are more incline to the type of extreme Yin & Yang,namely character of Taiyin,Taiyang are the main outer display model:The score of Taiyang is fewer and that of Taiyin is more,which is main hazard factor of cerebral infarction patients.It manifests that five-state character and cerebral infarction onset has marked dependablity.4.7 Innate Innateness has dependablity with stroke onset.