The Retrospective Study Of Blood Stasis Syndrome In Advanced Non-small Cell Lung Cancer

objective Through the retrospective clinical study,to investigate distribution regularity and characteristics of blood stasis syndrome in advanced non-small cell lung cancer and further to analyze the correlation between blood stasis syndrome and pathological types,tumor stage,haemostasis markers,combination syndromes etc,and then to provide reference for clinical treatment of blood stasis syndrome. Method We took the patients of advanced non-small cell lung cancer from Dong Zhi Mei hospital and Bei Jing hospital of traditional Chinese medicine(TCM) during the recent five years as study cases,and made investigation table,collected cases.Using descriptive analysis to recognize the distribution status of general materials,information of disease and every haemostasis markers,and according to the diagnostic criteria of blood stasis syndrome,these cases were divided into blood stasis syndrome group and non-blood stasis syndrome group.①to analyze the composition ratio and combination syndromes distribution characteristics of patients with blood stasis syndrome;②to analyze the correlation between blood stasis syndrome and general materials, pathological types,tumor stages,every combination syndromes, haemostasis marker APTT(activated partial thromboplastin time),PT (prothrombin time),TT(thrombin time),Fbg(fibrinogen),D-dimer.Results①Among the collected 257 cases of advanced non-small cell lung cancer,Qi deficiency,yindeficiency,phlegm dampness and blood stasis were all common clinical syndromes,and composition ratio of blood stasis among these syndromes was 72.37%;②Among these syndromes of advanced non-small cell lung cancer,Yin deficiency had a tighter correlation with blood stasis than other syndromes,comparing with non-blood stasis syndrome composition ratio of Yin deficiency was significantly increased in blood stasis syndrome;③In advanced non-small cell lung cancer,blood stasis syndrome had no correlation with general materials of age,sex,family disease history,treatment experience etc and pathological types,but had some correlation with ECOG performance score and the staging of the tumor,with the increase of staging and ECOG score,blood stasis syndrome were with increasing trend;④Comparing with non-blood stasis syndrome of advanced non-small cell lung cancer,D-dimer level of patients with blood stasis syndrome was obviously increased with a significant difference,and also had a significant positive correlation with blood stasis syndrome in multifactor Logistic regression analysis.Conclusion①In advanced non-small cell lung cancer,blood stasis syndrome was prevalent and more common than other syndromes;②Qi deficiency,yin deficiency and phlegm dampness,which were common syndromes of lung cancer in clinic,all were recognized as primary influencing factors of blood stasis syndrome,but comparing with non-blood stasis syndrome,there was an obvious pathological characteristic of yin deficiency causing blood stasis in blood stasis syndrome of advanced non-small cell lung cancer;③The correlation between ECOG score,tumor staging and blood stasis syndrome,not only reflected some links between blood stasis syndrome and tumor proliferation,matastasis,and thereby ECOG score and tumor staging may were taken to be as important factors for prognosis,but also ECOG score and tumor stage may also provide the basic foundation for disease differentiation of TCM in blood stasis syndrome diagnosis and treatment;④The significant correlation between D-dimer and blood stasis syndrome not only reflected tumor hypercoagulative status in the patients of blood stasis syndrome,but also,to some extent,reflected the blood stasis syndrome essentials of advanced non-small cell lung cancer in terms of blood coagulation disfunction,and then it may was very useful to be taken as a micro-index for clinical diagnosis of blood stasis syndrome;⑤According to the characteristics of blood stasis syndrome combination syndromes and its correlation with blood stasis syndrome, we consider that strengthening qi and nurishing yin,activating blood and removing phlegm should be the basic strategy for the treatment of blood stasis syndrome of advanced non-small cell lung cancer,it not only embodieded the advantage of treatment based on syndrome differentiation of TCM,but also embodied the unity with tumor therapy.