Relevance Study Between Blood Stasis Syndrome Of Mid And Late NSCLC Patient And Relevant Symptoms And Portion Of Laboratory Index

The study can be divided into two parts, past and present case studies. Past case data comes from 201Ⅲand IV stage NSCLC patients of Guanganmen hospital from 1999 to 2004, the data includes every patient's symptom and signs. The study did not involve laboratory index, in order to further research the relation between primary non-small cell lung cancer and blood stasis syndrome, we did deeper research on 70 III and IV stage NSCLC patients of Guanganmen hospital from November 2010 to March 2011. Not only detail record every patient's symptom and signs in questionnaire, but also carry out the blood stasis syndrome related index lab testing, expecting to offer object evidence of their relationship.1 Research objectThe first part of the research object is III and IV stage NSCLC 201 patients of Guanganmen hospital from November 1999 to December 2004.The second part is III and IV stage NSCLC 70 patients of Guanganmen hospital from November 2010 to March 2011.2 Research methods2.1 Relevant factor of patient's symptom and signs investigationWe formulate "mid and late NSCLC patient and blood stasis syndrome relevant symptomatic questionnaire".The references are primary lung cancer diagnostic criteria , blood stasis syndrome diagnostic criteria, primary lung cancersymptom classification diagnostic criteria, blood stasis symptom classification diagnostic criteria[4] and mid and late primary lung cancer blood stasis symptom quantificationdiagnostic criteria. And the final relevant factor index are coughing, bloody sputum, dyspnea, chest pain, chest stuffiness, fever, expectoration, fatigue, anorexia, dry mouth and throat, palpitation, fuss and insomnia, spontaneous sweating, nausea, diarrhea, constipation, sharp pain, fixed-point pain, unpalpable, vein blood stasis, bleeding, dysmenorrhea, black blood clot of menstruation, amenorrhea, tongue dark purple, tongue deposition spot, uneven pulse, scaly dry skin, limbs numb or hemiplegia, mentally deranged, mania and amnesia, trauma history, surgery history and artificial abortion.The first part of the caseswas from the signs and symptoms questionnaires,201 cases from 1999 to 2004. The second part of the cases (70 cases from2010-2011) are face to face observation records, in order to ensure the objectivity and accuracy of observation, using the way of one person watch and take notes, another person check to reduce the bias of different observer's subjective judgment.2.2 Relevant laboratory index testAccording to mid and late primary lung cancer blood stasis syndrome quantification diagnostic criteria5 laboratory index proposed by Zhang Peitong team, the final relevant laboratory index are platelet count, FIB, D-polymer and CD61, CD62 AND PAC-1 of blood cells surface adhesion molecule.2.3 Data processing2.3.1 Relevant factors of patient symptom and signs(1) According to the obtained information and blood stasis syndrome diagnostic criteria from "mid and late NSCLC patient and blood stasis syndrome relevant symptomatic questionnaire", all cases were divided into blood stasis syndrome and non-blood stasis syndrome. The former were classified by soft, medium and heavy according to mid and late primary lung cancer blood stasis syndrome quantification diagnostic criterialaboratory index proposed by Zhang Peitong team.(2) Observation symptom and signs were divided by being and not being, and positive symptom and signs were classified by soft, medium and heavy according to primary lung cancer classification diagnostic criteria.(3) The research statistic analyzed both cases to find out similarities and differences.2.3.2 Relevant laboratory index test Relevant laboratory index tests only involve the second research object,70 patients from 2010 to 2011.Blood cells count, FIB, D-II polymers were divided into normal and abnormal groups according range of normal values. CD61, CD62 and PAC-1 only reserved detection value.2.4 Statistic methodAll statistic methods applied SPSS 17.0, Excel 2003, measurement data expressed by mean and standard deviation. Ranked data are expressed by bivariate correlation analysis.3 Results3.1 The relevance of mid and late NSCLC 201 patient blood stasis syndrome and relevant symptom from 1999 to 2004.The data analysis of mid and late NSCLC 201 patient from 1999 to 2004 showed that blood stasis syndrome have notable relation with stabbing pain, vein blood stasis, bleeding, tongue dark purple, amnesia, palpitation, dry mouth, chest pain and blood-stained sputum (P<0.1). Lung cancer blood stasis syndrome level have notable relation with stabbing pain, bleed, chest pain and blood-stained sputum and signs (P<0.01), and relation with tongue dark purple, fatigue (P<0.05). There is no obvious relation between all lung cancer blood stasis syndrome relevant symptoms and signs level and blood stasis syndrome level (P>0.05). All lung cancer blood stasis syndrome relevant symptoms and signs level have some relation withthe existence of blood stasis syndrome, including blood-stained sputum and fatigue (P<0.05).3.2 The relevance of mid and late NSCLC 70 patient blood stasis syndrome and relevant symptom from 2010 to 2011.The data analysis of mid and late NSCLC 70 patient from 2010 to 2011 showed that blood stasis syndrome have notable relation with stabbing pain, vein blood stasis, tongue dark purple, chest pain (P<0.01). And it also had relation with bleed, uneven pulse, dry mouth and in-appetence(P<0.05). Lung cancer blood stasis syndrome level have notable relation with vein stasis and blood-stained sputum (P<0.01). And also had relation with chest pain(P<0.05). All lung cancer blood stasis syndrome relevant symptoms and signs level have statistic relation with blood stasis syndrome level, including blood-stained sputum and fatigue (P<0.05). There is no relation between all lung cancer blood stasis syndrome relevant symptoms and signs level and the existence of blood stasis syndrome (P>0.05).3.3 The relevance of mid and late NSCLC 70 patient blood stasis syndrome and relevant symptom from 2010 to 2011.Blood stasis syndrome relevant laboratory index studies showed that there was no correlation between the existence of blood stasis syndrome and normality of PLT, D-II, FIB (P>0.05). And there is no statistic relation between lung cancer blood stasis syndrome level and normality of PLT, D-II, FIB (P>0.05). The existence of lung cancer blood stasis syndrome had correlation with the value of PLT (P<0.05), but had no statistic correlation with D-II, FIB, CD62-/PAC-1+(%), CD62+/PAC-1+(%), CD62+/PAC-1-(%) (P<0.05). Lung cancer blood stasis syndrome level had correlation with CD62+/PAC-1+(%) and CD62-/PAC-1+(%) (P<0.05), but no statistic correlation with D-Ⅱ, FIB,PLT, CD62+/PAC-1-(%) (P>0.05).3.4 The comparison of 201 cases from 1999 to 2004 and 70 cases from 2010 to 2011 By contrasting two cases, we found that stabbing pain, vein stasis, bleed, tongue purple, chest pain and dry mouth had no correlation with the existence of blood stasis syndrome, but bloody sputum had.4 Conclusions4.1 Stabbing pain, vein stasis, bleed, tongue dark purple, chest pain and dry mouth had important diagnostic significance to NSCLC. Stabbing pain, vein stasis, bleed, and tongue dark purple is diagnostic basis of blood stasis syndrome diagnostic standard, while chest pain and dry mouth are common symptom of primary lung cancer.4.2 The rising of platelet count had important diagnostic significance to NSCLC.4.3 The existence of blood stasis syndrome had no correlation with the normality of D-II polymers, FIB and specific test values, this is different from past research results.4.4 Primary NSCLC level have positive correlation with CD62+/PAC-1+(%) and CD62-/PAC-1+(%). The proportion is higher,the blood stasis syndrome is heavier.5 Problems and prospects5.1 This study time is limited and sample size is few, it may reduce the typical to some extent. Therefore, we need bigger sample to make the conclusions more convincible.5.2 This study is single disease and single document, gives the III and IV stage NSCLC patientssymptoms and signs level and blood stasis syndrome level detailed classification and bivariate analyses, gives the normality of blood stasis syndrome relevant laboratory index and specific test values and the existence of blood stasis syndrome level bivariate analyses, combines subjective judgment and objective indicator, macroscopic observation and microcosmic detection. However, the patients' situation are complex, blood stasis syndrome patients also have other symptoms. Further study should detach multiple symptoms to single symptom as much as possible, get more accurate data, and discuss correlation and differentiation between blood stasis syndrome of the traditional medicine and "high sticky" blood of modern medicine, to build bridges of mutual understanding of different medicine models.