Organs Early Stroke Symptoms And Eeg Monitoring And Short-term Prognosis

Chinese people realized the important role of brain before 2000 years,but the theory of brain developed slowly untile Ming and Qing dynasty it's importance was attached little by little.The recognition and researches of brain in Chinese Medicine are penetrating deeply and have got some new progressions for the past few years.Apoplexy is one of the common brain diseases.Achievements of researches in Chinese Medicine about apoplexy enriched the theories of brain,impulsed researches in function of brain,causes and pathogenesis of brain diseases.1 ObjectiveSum up the main theories of brain in Chinese Medicine.Analyze the feature of early symptoms and short-term prognosis in apoplexy involving the fu or zang -organs.Research in the electroencephalogram(EEG) characteristic of apoplexy involving the fu or zang-organs and it's short-term prognosis significance.2 Methods2.1 Theories summarySum up the theories in Huangdi Neijing,refer to antiquity books and contemporary literatures to sum up the discussions about brain and the development of apoplexy recognition.2.2 Clinical symptom analysisSelect the clinical data of National Point Foundation Research Development Plan(973 plan) 'Ischemic Stroke Diagnosis Combining Symptoms and Signs of Disease and Effect Evaluation System Research' of patients in apoplexy involving the fu or zang-organs in 7 days afer apoplexy onset.For patients of initial appear apoplexy involving the fu or zang-organs collect the symptoms and score of NIHSS the day admission,for patients who were appear apoplexy involving the fu-organs or zang-organs in 7 days of apoplexy involving meridians onset collect the symptoms the day apoplexy involving the fu-organs or zang-organs onset and the higher score of NIHSS.Collect every patients' score of NIHSS of 28^th day after apoplexy onset.Divide the patients into 3 groups according died or NIHSS score improve 18%:good outcome,poor outcome and died groups.Use factor analysis and logistic regression analysis to analyse the data.2.3 Electroencephalography monitoringInclude patients of apoplexy involving the fu or zang-organs in 48h of symptoms onset and start 24h electroencephalography monitoring befor symptoms onset.Grade the electroencephalogram according Synek standard and use rank sum test to approach the contrast of electroencephalogram between died and survived groups.Use mathematical technique to extract the feature of amplitude and frequency of wave and compare the difference between normal people and survived and died groups.3 Results3.1 Theory summaryWe could make out that the theories about brain in Huangdi Neijing are very aplenty though the discussion is scattered so the latecomer didn't pay attention to it.Till Ming and Qing dynasty especially after the introduction of Western medicine the position of brain theories were promoted and the theories became more abundant.The knowledge of apoplexy in Chinese Medicine experienced a procedure from exogenous pathogenic wind to endogenous wind theory,and in several decades it's generally accepted that the location of apoplexy is in brain. Apoplexy is one of the brain diseases.These knowledges profit the research of apoplexy.3.2 Symptoms analyse of ischemic stroke involving the fu or zang-organsThere are 12 factors obtained through factor analysis include 5 syndrome essential factors phlegm,fire,wind,deficiency of qi and deficiency of yin.Wind factor is the most important one involved and the factor of deficiency of qi and deficiency of yin also account large proportion.Logistic regression analysis discovered that the symptoms correlate with outcome are consciousness,flushed cheeks,anisocoria,accelerated breathing,gruff breathing,fever,spontaneous perspiration,dry stool and foul breath.3 Electroencephalography monitoring22 patients were included and no patient's electroencephalogram was normal. Special types of electroencephalogram include 1 spindle coma and 3α,θcoma, and 1 patient's electroencephalogram appeared spike and slow wave complex. Most electroencephalogram appeared no main rhythm,middle or high amplitudeθ,δwave diffusibility.Rank sum test discover that grades of electroencephalogram are different in survived and died groups.The feature extractioned display that all patients were different from normal people,the died group were more different.4 ConclusionThe principal early symptoms of ischemic stroke involving the fu or zang-organs are wind syndrome appearance and involve in 5 of the 6 syndrome essential factors phlegm,fire,wind,deficiency of qi and deficiency of yin except blood stasis.Poor consciousness,flushed cheeks,anisocoria,accelerated breathing and fever indicate poor short-term prognosis while gruff breathing,foul breath, spontaneous perspiration,dry stool indicate good short-term prognosis.Electroencephalography monitoring can help to define short-term prognosis in apoplexy involving the fu or zang-organs by grade the electroencephalogram or mathematical technique.The mathematical technique remain to be confirmed by large sample trail.The changes within long time monitoring can also help judge prognosis and quantitative analysis should be made in the future.