Study Of Academic Thought And Experience In Treatment For Rheumatoid Arthritis Of Professor Dai Yu-guang

My doctoral supervisor,professor Dai Yuguang has been engaging in doctor for more than forty years.He has a solid foundation in Chinese Traditional Medicine,and a great deal of experience in clinical.Rheumatoid arthritis(RA) is a chronic systemic autoimmunity disease which threatened human's health. Jiajiandangguiniantong Tang had a good effect to treat RA.Professor Dai Yu-guang is experienced in treating RA with Jiajiandangguiniantong Tang in its acute stage of combination of wind,dampness and pyretic stagnation pattern.This research carries on a study on anti-inflmmation,immunity and treatment mechanism to RA of Jiajiandangguiniantong Tang.To study the experience and prescription of professor Dai by analyzing the frequency of drugs,the class of efficacy,the property and flavor,the meridian distribution,and the dosage of drugs.We summarize the cognition of rheumatoid arthritis in TCM through literature retrieval and induction.76 RA patients were divided into 2 groups,including 12 males and 64 females,who were diagnosed as moist heat arthralgia spasm syndrome during march 2006 to march 2008.The average age was 46.6±5.3,and average course was 5.3±6.7 years.The control group was taken methotrexate(MTX) plus leflunomide,while experimental group was treated with therapeutic alliance of MTX,leflunomide and Jiajiandangguiniantong Tang.The course of treatment was 12 weeks.The effect was evaluated by number of tenderness joints,number of swelling joints,ESR,Visual analogue scale of global disease activity estimated by the patient(VAS),Disease Activity Score in 28 joints(DAS28),recover rate whether reaches standard of American College of Rheumatology 20%,50%,70% improvement criteria(ACR20,ACR50,ACR70),and adverse effect after treatment finished.Took adjuvant-induced arthritis rat as experimental model,treat with Jiajiandangguiniantong Tang,observed the anti-inflmmation,and treatment mechanism of Jiajiandangguiniantong Tang from the view of pharmacology, pathology,cell multiplication,ELISA.The study showed that the two groups all produce a remarkable effective in early morning stiffness,number of tenderness joints,number of swelling joints, ESR,VAS score(by patient),DAS28(P＜0.05).The recover rate was much higher in experimental group than in control group.(P＜0.05).The incidence of adverse effect was quite low in each group,and had no significant difference.2). Jiajiandangguiniantong Tang has obviously effect of anti-inflammation,inhibition swelling of joints,reduce the arthritis index score,perimeter of ankle and thickness of calw.It can also lighten the synovial inflammation and the lesion of joints distinctly,and prevent the joint cartilage and bone from destruction. PMA-induced spleen lymphocytes proliferation in rat and the serum level of IL-1 and TNF-αin adjuvant-indued arthritis rat could also be inhibitied by Jiajiandangguiniantong Tang.We summarized the learning thought and clinical experience of professor Dai Yuguang.Jiajiandangguiniantong Tang could significantly improve reactiveness indexes of RA,lessen pathogenetic condition,with no adverse effect.This decoction can inhibit spleen lymphocytes proliferation,decrease the serum level of IL-1 and TNF-αin adjuvant-indued arthritis rat,which may be one of the therapeutic mechanisms of Jiajiandangguiniantong Tang on RA.