Fc¦ÃR-IIIA Gene Polymorphism And Systemic Lupus Erythematosus

Background.Patients with systemic lupus erythematosus(SLE) and lupus nephritis(LN) exhibit defect of phagocytosis in immune complex(IC) processing.IgG Fcγreceptor is important in the clearance of IC.FcγR-ⅢA has higher affinity for certain IgG subtype which plays a major role in the pathogenesis of lupus nephritis. The polymorphism of FcγRⅢA predicts different ability of IC clearance.Objective To study whether the FcγRⅢA polymorphism is a risk factor for systemic lupus erythematosus(SLE),lupus nephritis(LN) and early onset lupus nephritis in Asian. Methods.We genotype 100 Chinese SLE patients(76 patients with LN) and 127 normal controls for FcγRⅢA polymorphism,then perform a meta analysis based on the Medline,Embase and CNKI databases(lase retrieval June 2008),as well as assessment of pertinent articles and references.Result.No association is found between FcγRⅢA polymorphism and SLE or LN in case-control research,neither is association between FcγRⅢA polymorphism or course of lupus nephritis.But in meta analysis,skewing is found between genotype FF and SLE(OR=1.26[1.06-1.56], P=0.03),so is between allele F and SLE(OR=1.26[1.01-1.43],P=0.04).Conclusion. The homozygous FF genotype and F allele of FcγRⅢA may be the risk factors for systemic lupus erythematosus.No association is found for LN and early onset lupus nephritis.