The Refractoriness Of Chronic Eczema And Relative Clinic And Experiment Study

Objective:To study the refractoriness of chronic eczema,therapeutic effect of hepatic and renal yin deficiency type chronic eczema with Ziyinhuoxue Wate and the role of CCL17,CCL18,CCL22,CCL24,CCL26 in IgE-relative eczema.Methods:100 cases of patients with chronic eczema of hepatic and renal yin deficiency type were randomly divided into treatment group(with Ziyinhuoxue Wate),control group(with Wushezhiyang pill),observed clinic efficacy, detected CCL17,CCL18,CCL22,CCL24,CCL26 in blood and skin biopsy by ELISA and RT-PCR analysis.Results:Ⅰ.Two groups were all improved to a certain extent in symptom,physical sign and EASI scores after intervention.Total effective rate was 93.5%in treatment group,76.3%in control group.It was significant different in statistics between two groups(P＜0.01).It was better in treatment group than control group.EASI scores were decreasing after treating in two groups,and EASI difference before and after treating was bigger in treatment group than control group,P＜0.05. eczema patients and significantly correlated with the disease severity,EASI scores and IgE level,but CCL24 no.Ⅲ.CCL17 and CCL18 were clearly detected in skin tissues by Immunohistochemical staining from all chronic eczema patients,but not in those from normal donors.CCL17,CCL18,CCL22,CCL26 were detected in skin tissues by RT-PCR from all chronic eczema patients,but not in those from normal donors.Ⅳ.Plasma CCL17,CCL18,CCL22,CCL26,IgE levels were decreased in IgE-relative chronic eczema patients with Ziyinhuoxue Wate and in line with the disease and lesion improving,but CCL24 no.Conclusions:It was refractory for Chronic Eczema because of complicated and indefinite etiopathogenisis,indefinite pathogenesis,multitude diagosis grouping, and unsatisfactory therapeutic effect especially long-term therapeutic effect.It was good for hepatic and renal yin deficiency type chronic eczema with with Ziyinhuoxue Wate.CCL17,CCL18,CCL22,CCL26 were significantly correlated with the disease reactiveness and involved in the pathogenesis of IgE-relative chronic eczema.