Effects Of RuanPi Tablet On Treatment Of Systemic Sclerosis And Hemorheology, Cor, CEC, ET-1, MMP-1 And TIMP-1

Objective:To afford theoretical foundation for YiPiZhiPi Therapy by lots of documentary research, and to explore the effects of RuanPi Tablet for Systemic Sclerosis and the influence of RuanPi Tablet on the indices of hemorheology, the number of circulating endothelial cell(CEC), the plasma levels of cortisol(Cor) and endothelin-1(ET-1), the serum levels of Matrix metalloproteinase-1(MMP-1) and Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1).Methods:61 patients with Systemic Sclerosis were divided randomly into the test group treated with RuanPi Tablet and the control group with Tabellae Centellae Triterpeni. fhe therapeutic effects were evaluated, the indices of hemorheology, the number of CEC, the plasma levels of Cor and ET-1 and the serum levels of MMP-1 and TMP-1 were measured.Results:1 The total effective rate of RuanPi Tablet was 96.77%, which was remarkable than that of Tabellae Centellae Triterpeni (P<0.05).2 RuanPi Tablet could reduce skin sclerosis scores and improve maximal oral opening.3 RuanPi Tablet could significantly improve the indices of hemorheology, increase the plasma Cor level and the serum MMP-1 level, decrease the number of CEC, the plasma ET-1 level and the serum TMP-1 level.Conclusions:RuanPi Tablet is effective for Systemic Sclerosis and its mechanism may be related to improvement of microcirculation, regulation of endocrine-immune function, protection of vascular endothelials and restriction of fibrosis.