Study On The Clinical Efficiency And Inflammatory Mechanism Of Ultra-podwer Wuji Pill On Patients With Gastric Ulcer In Syndrome Of Stomach And Liver Stagnation-hot

Objective:To evaluate the clinical efficiency of ultra-podwer Wuji Pill on patients with gastric ulcer in syndrome of stomach and liver stagnation-hot,and discuss its effect on Anti-HP from expression of Inflammatory factors IL-6,IL-8 and TNF-a.Methods:1.According Chinese medicine clinical research in accordance with the requirements,evaluating the clinical efficiency,Gastroscopy result, Inflammatory factors IL-6,IL-8 and TNF-a of ultra-podwer Wuji Pill on patients with gastric ulcer in syndrome of stomach and liver stagnation-hot.2.Using gastric ulcer model in Hp infection,animals were randomized, administrated respectively and detecting content and expression of IL-6,IL-8 and TNF-a by ELASA and Immunohistochemistry method.Results:1.Clinical efficiency,Syndrome efficiency,Gastroscopy effect and clearance rate of HP of ultra-podwer Wuji Pill on patients with gastric ulcer in syndrome of stomach and liver stagnation-hot was 80.3%.90%.33.3%and 66.7%,compared with traditional Wuji pill group,there was not significant difference(p＞0.05). 2.1/3 dosage ultra-podwer Wuji Pill group can narrow ulcer area of HP infected model,decrease expression of IL-6,IL-8 and TNF-a in rat model,which compared with traditional Wuji pill group and sanjiu weitai group,there was not significant difference(p＞0105).Conclusion:1.Ultra-podwer Wuji Pill can significantly improve clinical efficiency,Gastric mucosal area,regulate Serum levels of inflammatory factors,which shows it is an ideal anti-HP drugs.2.Ultra-podwer Wuji Pill can fairly clear up HP which leads to gastric ulcer, reduced expression of IL-6,IL-8 and TNF-a.