| Psoriasis is a common chronic ,recurrent, inflammatory disease of the skin. Psoriasis is a complex disease resulted from various etiological factors under the genetic background. It has comlex pathogenic mechanisms that cannot be explained by now. It tends to be recurrent attacks, but the effective radicular curative drugs and means are scarace . And there is no breakthrough in the therapy to Ps with both the TCM and the western medicine .Obviously the curative effect of the western medicine in the near future is effective ,but with the long-term toxicity and side-effect. Treatment for Ps with traditional Chinese medicines has many advantages: positive effect but little side effect. So treatment to Ps with the TCM and external use is a better means by now.This paper includes literature reviews and research reports.Two literature reviews are included. The first reviews modern clinic and research development on the Ps. It gains special concerns of the academic circles' owing to its unknown etiological factors and pathogenesis. Besides, it is scarce of effective therapeutic tools. Considerable research has been performed on epidemiology, etiological factors, pathogenesis and therapy in recernt years. The second reviews Traditional Chinese clinic research and development on the Ps including its successive changes, the opinions of neoteric doctors on irs pathogenesis, medicial and surgical treatment.This research reports are consisted of three parts.First is the standardization of psoriasis about dieffrentiation - based treatment and the herbs. 110 prescriptions are collected to statistically analyzed. Most TCM doctors are likely to divide the Syndrome of Ps. to three kinds:blood heat, blood dryness and blood stasis .Accoridingly differently herbs are used to treat the three kinds Ps. above. Standardization of treatment to psoriasis with Chinese medicine is useful to improve levels of using Chinese medicine to treat Ps.The second is about the clinic research. We have performed clinicial verification on blood-heat syndrome applying with the Liangxuejiedutang(LXJDT) and external drug-the Jiaweihuangqinyougao(JWHQYG) to approach its effect. There are 60 cases with blood -heat syndrome who are all use the external drug-the JWHQYG included in the clinical verification, and 30 applied with the LXJDT and the other 30 cases applied with the Fufangqingdaijiaonang(FFQDJN) for control. After two months treatment, the PASI scores on lesions of the two groups are different significantly from those two months ago.The clinical effective rate is up to 76.7%, total effect rate is 100%in LXJDT group;While in control group is 23.3% and 90% respectively.There is remarkable difference between the two groups.The last one is about experimental research.The experiment consists of two texts.In text one ,we use the SEB as the superantigen to produce the TNF in the mouses' blood. And then observed that different treatment to make TNF to reduced down to different levels. We concluded that all the treatment with Chinese herbs are remarkable reduced TNF levels.In the model text of Jarrett, all the groups with Chinese herbs including the group of FFQDJN with JWHQYG(groupC),the group of LXJDT with JWHQYG(groupD) ,the group of LXJDT with Keyinlingruangao(KYLRG)(group E) can significantly prompt the formation of the scale epidermis cells of the tail(P<0.05). But group E compared with group D and C is higher(P<0.01).All the researches indicated that applying LXJDT with KYLRG is the better way in treating blood-heat syndrome of Ps. |
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