Research Of Glial Fibrillary Acidic Protein (GFAP) In Patients With Hypertensive Cerebral Hemorrhage After Mini-invasive Hematoma Aspiration

Objective:To study the concentration of serum glial fibrillary acidic protein (GFAP) in the patients with hypertensive cerebral hemorrhage after minimally invasive surgery(MIS).and the correlation between the content of GFAP and the volume of bleeding,the areas of cerebral edema as well as The nerve function deficiency score(NDS).in the patients with acute cerebral hemorrhage.Methods:154 patients with acute cerebral hemorrhage and 60 normal controls were recruited from Shandong provincial hospital and Shandong traffic hospital and Laiwu people hospital,the cerebral hemorrhage group were chosen after the symptom happens in 24 hours.Checked by CT or MRI on morbidity and 3 day after then and Calculating ICH and perihematomal edema volumes according to CT or MRI. The ICH volume on admission is more then 30ml.The blood sample was obtained in the first day,the third day,the seventh day,the fourteenth day after disease onset,the serum GFAP was detected by enzyme linked immunosorbent assay(ELISA).The volume of bleeding and the areas of cerebral edema were calculated by cranium CT. The nerve function deficiency score(NDS) was conducted in the day of getting blood..Results:(1) The content of serum GFAP in cerebral hemorrhage group significantly increased in the first day,it went to climax in the seventh day,it was still significantly higher than that in control group in the fourteenth day.(2) The level of serum GFAP had positive correlation with the volume of bleeding and the areas of cerebral edema and the NDS.(3) The level of serum GFAP in the MIS group significantly decreased in the seventh day and the fourteenth day.Conclusions:(1) The Serum GFAP had positive correlation with the volume of bleeding,which indicates that it can reflect damage degree of the brain tissue.(2) The content of serum GFAP could be used as clinical biomarker to judge the size of cerebral edema after cerebral hemorrhage.(3) The content of serum GFAP had significant correlation with the NDS of the patients with cerebral hemorrhage,and they are simple,cheap,effective blood pretest indexes for cerebral hemorrhage. (4)Mini-invasive hematoma aspiration can decrease the serum leve of the GFAP in patients with cerebral hemorrhage.Serum GFAP is a potential marker for prognosis and outcome in patients with minimally invasive surgery.