Clinical And Experimental Study Of Jin' 3-needle Therapy For Treatment Of Apoplectic Hemiplegia

Objective:To evaluate the influence of Jin'3-needle therapy on the hemiplegia motor functionandactivities of daily living in patients with apoplectic hemiplegia, and to investigate the effect and mechanism of Jin'3-needle therapy intreating apoplectic hemiplegia by experimental study and provide using Jin' 3-needle and bone marrow stem cells(BMSCs) therapy in apoplectic hemiplegia.Method:Clinical study:one hundred and thirty-five patients were equally randomized into three groups.Jin'3-needle therapy group (45cases),Rehabilitation group (45cases),Jin'3-needle and rehabilitation group (45cases), The degree ofhemiplegia motor functionandactivities of daily living in patients with apoplectic hemiplegia were assessed with Fugl—eyer assessment(FMA)'and Barthel index before and after treatment.Animal experimental study:forty SD rats were randomly divided into five groups: the pseudo operated group, the model group (operated), Jin'3-needle therapy group, BMSCs groups, Jin'3-needle and BMSCs therapy group. The rats cerebral ischemic strokemodel were subjected to focal ischemic by middle cerebral artery occlusion(MCAO)using intraluminal thread. The neurologic impairment scoring, cerebral ischemic area measured by TTC-staining were observed and compared between groups.Results:Clinical study:After 14 days and 28 days treatment, the FMA and Barthel index values of all of the three groups are better than before (P<0.01).After 14 days, there were no significant difference among the three group with the values of FMA and Barthel index;after 28 days, there were significant difference between the Jin'3-needle therapy group and rehabilitation group with the values of FMA, there were significant difference between the Jin' 3-needle and rehabilitation group and rehabilitation group with the values of FMA, there were significant difference between the Jin'3-needle therapy group and rehabilitation group with the values of Barthel index. And there was no severe adverse reactions in patients caused by Jin'3-needle therapy. Animal experimental study:to compare the pseudo operated group,the model group (operated), Jin'3-needle therapy group, BMSCs groups, Jin'3-needle and BMSC therapy group has improved neurologic impairment, cerebral ischemic area measured by TTC-staining, and Jin'3-needle and BMSCs therapy group has more BMSCs in prostomial ganglion.Conclusion:Jin'3-needle therapy on the patients of apoplectic hemiplegiahas a difinite therapeutic effect on the hemiplegia motor functionandactivities of daily living. There will be a better therapeutic effect if to match rehabilitation. Jin'3-needle has no obvious function to has more BMSCs in prostomial ganglion, but the effect of to focuses is obvious in the pictures of animal experimental study.