Traditional Diagnosis Of Blood Stasis Syndrome Of The Mathematical Model

Blood stasis syndrome, which is one of the most common diseases in the Chinese clinic, is the common syndrom of cardiovascular, cerebrovascular and many other complicated and serious diseases. Research on blood stasis is the major demand of prevention and treatment of the complicated and serious diseases in our country. On the other hand, in every syndrome differentiation system of traditional Chinese, blood stasis syndrome belongs to blood syndrome, the differentiation of qi, blood and fluid and it belongs to the common syndrome of the important organs like heart, brain, liver,the zangfu-organs differentiation, so blood stasis syndrome is the great foudation of Chinese medical diagnosis and treating diseases. Research on the standardization, quantification and modeling of blood stasis syndrome has great practical and theoretical significance in the whole standardization research of Chinese medicine syndrome.Therefore, under the guidance of traditional Chinese medicine theory, inheriting traditional Chinese thinking, following the evidence-based medicine concept, collating literature related to blood stasis and the previous ideas, inheriting and carrying forward the essence of ancient literature and combining with the experence and characteristics knowledge of the symptoms and signs of blood stasis syndrome by the modern experts, this study plays the role of expert groups to prepare a scientific and reasonable questionnaire about blood stasis syndrome and the related factors. On this basis, through the information entropy, traditional differentiation diagnosis fuzzy sets are established by fuzzy mathematics method and the main symptoms and signs of blood syndrome subtypes are selected by the use of fractal mathematics, making the blood stasis syndrome diagnosis more clear and the prescriptions more precise. And this study explores the establishment ideas and methods of mathematical models of Chinese medicine syndrome diagnosis. The research results are as follows:First, collating the ancient and modern literature about blood stasis syndrome and counting the main symptoms and signs of blood stasis syndrome. On this basis, through a questionnaire survey of experts, the clinical associate professors or above in the first affiliated hospita of Guangzhou university of traditional Chinese medicine for screening survey of blood stasis syndrome selected items, it explores the macro-differentiation diagnosis of blood stasis syndrome from the viewpoints of clinicians. Therefore, based on the related symptoms and signs of ancient and modern literature and the combination of pre-test results, the research group has developed selected items of macro traditional diagnosis of blood stasis syndrome for the experts consultation questionnaire and carried out this work by the form of questionnaire survey. The experts'opinions show that the symptoms and signs like the dark purple tongue, fixed pain, pathologic tumor, petechiae tongue and varicose veins under the tongue are the main bases for macroscopic diagnosis of blood stasis syndrome clinically. In addition, during the consultation process, experts placed particular emphasis that the research should be combined with blood stasis diseases and the clinical efficacy will not be good enough if using drugs only according to the common performance like dark purple tongue. The experts questionnaire survey has great referential significance for the goal determination of selected items of macro traditional diagnosis of blood stasis syndrome and the post research. We will make out the macro diagnosis questionnaire form and do the post research according to the advice of expers and the literature.Second, combining with the literature research, experts questionnaire survey and the pre-test results, a clinical epidemiology survey form has been made for the greater coverage of macro-differentiation diagnosis of blood stasis syndrome. Strictly in accordance with DME and the survey design requiremennts for medical groups, a large sample of clinical epidemiology survey has been made for the blood stasis syndrome patients from every department like cardiology, neurology, gastroenterology, nephrology, pneumology, surgery, gynecology, pediatrics, hematology and oncology. According to the fuzzy mathematics method and the blood stasis syndrome diagnostic criteria made in the Beijing International Conference on blood stasis syndrome research in 1988 and combining with the clinical practice, the blood stasis fuzzy sets in macro diagnosis for men and women have been established separately. Compared with the blood stasis diagnostic criteria made in the Second National Academic Conference on activating blood and dissolving stasis research in 1986, the diagnostic results of these sets are quite similar, indicating that the sets have certain reliability, worthy of further verification and research. And the estabilshment of macro diagnostic fuzzy sets of blood stasis syndrome provides new ideas and methods for quantitative study of Chinese medicine syndromes.Third, using information entropy and according to the fractal ideas and methods, the clinical diagnosis data has been analyzed about 407 cases of blood stasis, every subtypes in-patients from the first affiliated hospital of Guangzhou university of traditional Chinese medicine, including blood stasis due to qi deficiency, qi stagnation, cold coagulation, heat stagnation, phlegm obstruction, ying deficiency, yang deficiency and blood deficieny syndrome, eight subtypes. The main symptoms and signs of every subtype of blood stasis syndrome are selected by the information contribution rate of those to every subtype. Accordiong to the information contribution rate, from big to small, the main symptoms and signs of blood stasis due to qi deficiency syndrome are shortness of breath, fatigue, fixed pain, dark pale tongue, varicose veins under the tongue and astringent pulse; the main symptoms and signs of blood stasis due to qi stagnation syndrome are dark purple tongue, hypochondrium distending pain, string pulse, chest tightness and depression; the main symptoms and signs of blood stasis due to cold coagulation syndrome are purple lips, cold hands and feet, local fixed pain,pain reduced by warmness and deep tight pulse; the main symptoms and signs of blood stasis due to heat stagnation syndrome are crimson and purple tongue, high fever, dry mouth and throat, fixed pain and bleeding; the main symptoms and signs of blood stasis due to phlegm obstruction syndrome are dark purple tongue, petechiae tongue, cough with sputum, chest tightness and fixed pain; the main symptoms and signs of blood stasis due to ying deficiency syndrome are dysphoria with feverish sensation in the chest, palms and soles, dark purple tongue, emaciation, fixed pain and dry mouth and throat; the main symptoms and signs of blood stasis due to yang deficiency syndrome are intolerance of cold, cold limbs, black complexion, fixed pain, shortness of breath, fatigue, deep and slow pulse and palpitation; the main symptoms and signs of blood stasis due to blood deficiency syndrome are pale,dim or sallow complexion, dark purple tongue, dizziness and blurred vision, thready and astringent pulse and numbness of limbs.This study is under the guidance of traditional Chinese medicine theory, following the evidence-based medicine concept, applying the principles and methods of clinical epidemiology, through making classical and modern literature research and clinical epidemiology survey and collecting clinical cases. On this basis, using the information entropy as the carrier and the thinking method of fuzzy mathematics and fractal mathematics, the traditional differentiation diagnosis fuzzy sets are established initially and the main symptoms and signs of every subtype of blood stasis are selected. In the Chinese medical research, the intrduction of mathematical methods, the establishment of mathematical models, the using of mathematical strcutures and the expression of mathematical language for the theory of Chinese medicine help to make Chinese medicine gradually develop into the track of quantification, standardization and modernization.