Treatment Of Tonifying Kidney On Chronic Kidney Disease: Theoretical And Clinical Study

Objective:To establish the theory of treatment of tonifying kidney (TK) on chronic kidney disease (CKD). Then, to investigate the effect and safety of TK treatment on Chronic renal failure (CRF).Methods:Theory study and clinical investigation were involed in this study. Selecting and analyzing classic and morden articles were the main methods of theory study. In clinical investigation, professor Sun's experience on the treatment of CKD was summarized first. Then 50 CRF (25 treatment group,25 conrol group) patients who were mainly treated by tonifying kidney were involved. During 3 months'treatment, their changes of syndrome pattern, rick factor of TCM, urinary protein, serum creatine, hemoglobin, serum albumin, and serum lipid were recorded and analyzed.Results:The essence of kidney insufficiency was essential qi insufficiency. Morden TCM kidney insufficiency refer to immunodeficiency, nerve-incretion disorder, turbulence of kidney focal blood stream. The exogenous and endogenous factors were the main cause of kidney insufficiency. The mechanisms of kidney insufficiency were dysfunction in essence-storing, disturbance in bladder, other organ disorder. Insufficiency included kidney qi, yin, yang, essence insufficiency. So tonifying kidney was the main treatment on CKD. Clinical study:The efficiencies were 76% (TK) vs 60% (contol) (P<0.05). In treatment group, patients'symptom scores were reduced significantly compared with initial level (P<0.05). There was no significant change in proteinuria in treatment group (P>0.05). But the proteinnuria was increased compared with initial level in control (P<0.05). After 3 months, there was decrease in Scr in TK group but increase in control group (P<0.05). There was no changes in hemoglobin compared with initial datas (P>0.05). After treatment, the level of Albumin was increased whereas that of control group was no change. TCH was increase in TK group but decrease in control (P<0.05). There was no changes in TG compared with initial level (P>0.05).Conclusion:Kidney insufficiency was the main mechanisms of CKD. Tonifying kidney was the main methods on treatment of CKD. TK treatment could relieve the discomfortable symptoms, improve quality of life, improve hemoglobin and serum albumin, stablize proteinuria, decrease SCr during 3 monthes. So it could improve the renal function.