Clinical Evaluation Of Xie Huang Decoction On Treating Recurrent Oral Uleer Patients

Background:Recurrent oral ulcers are more common oral mucosal diseases, the disease prevalence rate reaches as high as about 20%. At present western medicine with the disease may be immunity, infection, virus, spiritual factors related to the treatment of commonly used anti-inflammatory drugs, anesthesia, corrosive, immune enhancer, etc., the effect generally, a higher recurrence rate. The disease in traditional Chinese medicine is classified as "oral ulcers" or "aphthous", The pathological features of this disease include "Intense heat in heart-spleen", "Yin deficiency and heat bloom," the treatment of real fire is to purge fire, virtual fire to YangYinShengJin, There is a better clinical effect.Objective: Through the theoretical research and literature search,we discuss the different cognition and the research development between the traditional Chinese medicine and western medicine about RAU, counting and analyzing the treatment recurrence aphthous of mainly internal organs treated and the method by law, and searching the commonly used formulas to blend the significance and so on.Through clinical research,we discuss the clinical efficacy and safety of Modified Xie Huang powder on treating the intense heat in heart-spleen syndrome of RAU.Methods:The theoretical research and the literature search carry on the induction, the summary, the statistical analysis through the reviewing literature. Clinical research in accordance with the randomized, controlled the principle of the patients were divided into treatment group and control group, treatment group were Modified Xie Huang powder, medicine composition: gypsum, shanzhiside, Agastache rugosa, wind, raw licorice, berberine, calamus, ebony plum. Every day a medicinal preparation, when first seeing a doctor treatment, applies drugs continuously for 3 days, continues in the next month according to the first dosage to take medicine for three days, consolidated curative effect, two months later observes the recrudescence. The western medicine group and the control group was treated with vitamin B2 tablet lOmg/time,3 times/d, vitamin C tablets 0.2g/times,3 times/d, for 3days. When first seeing a doctor treatment, applies drugs continuously for 3 days, continues in the next month according to the first dosage to take medicine for three days, consolidated curative effect, two months later observes the recrudescence.Results: The literature study indicated: RAU clinical therapies commonly used governs the law mainly to concentrate in heat purging fire dampness in 33 cases (32.03%), spleen Act Yiqiwenyang 29 (28.16%), and Yin and Clearing Heat 16 cases (15.53%). Treatment of oral ulcers empirical formulas to Modified Xie Huang powder, guide scattered red, yellow soup spilled the highest repetition rate, followed by licorice Xie Xin Tang, Huanglian, deficiency of the prescription treatment of oral ulcers with Liu Wei Di Huang Wan, Yu Nvjian the highest repetition rate, followed by Pi Huanglian Ejiao soup. Clinical studies show: the treatment group syndromes total effective rate was 86.67%, total effective rate of the control group 56.67%; between the two groups was significant statistical difference; treatment group lesions total effective rate was 80.0%; control The total effective rate was 50.0%, a significant difference between the two groups. The main symptoms and signs results showed the treatment group and the control group the number of ulcers, ulcer pain, burning sensation, dry mouth and thirst, stool, tongue and other indicators are statistically significant (P<0.05).Conclusion: Treatment of Recurrent clinical approach to heat purging fire dampness, followed by spleen Act Yiqiwenyang and yang and nourishing yin and clearing heat. By law-based method; in the empirical treatment of oral ulcers purging fire to heat the main prescription detoxification; aphthous Deficiency of treatment with Yin, the intake of prescription-based, in particular, Kidney Yin, replenishing prescription. Modified Xie Huang powder treated in Recurrent oral ulcers of Intense heat in heart-spleen patients is effective and safe, can improve the ulcer size, ulcer number, ulcer pain, burning sensation, dry mouth, thirst, stool, tongue, obviously superior in the western group, Western group only ulcer itself improve the situation on the reaction of the body, such as dry mouth and thirst of indicators, stool, tongue, etc. showed no improvement, indicating Modified Xie Huang powder on the treatment of recurrent aphthous ulcers is an overall adjustment.